Advanced Research Projects Agency for Health

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Stored: Advanced Research Projects Agency for Health

Advanced Research Projects Agency for Health
Type: Research and Development Agencies
Parent organization: Department of Health and Human Services
Top organization: Department of Health and Human Services
Employees:
Executive: Director
Budget: 1500000000
Address:
Website: https://www.arpa-h.gov/
Creation Legislation: Consolidated Appropriations Act, 2022
Wikipedia: Advanced Research Projects Agency for HealthWikipedia Logo.png
Advanced Research Projects Agency for Health
This map created from a Cargo query (Purge)
Mission
ARPA-H aims to accelerate better health outcomes for everyone by supporting the development of high-impact solutions to society's most challenging health problems, driving biomedical breakthroughs from molecular to societal levels.
Services

Funding High-Risk, High-Reward Research; Biomedical Innovation

Regulations
Advanced Research Projects Agency for Health
Agency Overview
Formed March 15, 2022; 3 years ago (2022-03-15)
Jurisdiction Federal Government of the United States
Agency Executives Renee Wegrzyn, Director
Susan Coller Monarez, Deputy Director
Parent department Department of Health and Human Services
Website
arpa-h.gov

Advanced Research Projects Agency for Health (ARPA-H) is a U.S. government agency tasked with supporting transformative research to drive biomedical and health breakthroughs, focusing on projects that could not be readily accomplished through traditional research or commercial activity. It seeks to address health challenges through innovative, high-risk, high-reward research initiatives.

It is an agency within the Department of Health and Human Services.[1] Its mission is to "make pivotal investments in break-through technologies and broadly applicable platforms, capabilities, resources, and solutions that have the potential to transform important areas of medicine and health for the benefit of all patients and that cannot readily be accomplished through traditional research or commercial activity."[2]

Official Site

Mission

ARPA-H's mission is to accelerate the pace of biomedical breakthroughs to enhance health outcomes. By focusing on high-risk, high-reward projects, ARPA-H aims to catalyze innovations in health care, from molecular discoveries to societal applications, to provide transformative solutions for all individuals.[3]

Parent organization

ARPA-H is housed within the U.S. Department of Health and Human Services (HHS), contributing to the broader mission of improving health and well-being across the United States.[4]

Legislation

ARPA-H was established by the Consolidated Appropriations Act, 2022, which authorized its creation and provided initial funding.[5]

Partners

- Various federal, state, and local government agencies - Academic institutions for collaborative research - Non-profit organizations in health research and innovation

Number of employees

The exact number of employees at ARPA-H is not specified in the available references.

Organization structure

ARPA-H's structure is designed to foster innovation:

Leader

The organization is led by a Director.[6]

Divisions

  • Program Offices for managing specific research portfolios.
  • Innovation Office to scout for new ideas and technologies.[7]

List of programs

Last total enacted budget

ARPA-H received a budget allocation of $1.5 billion through Fiscal Year 2025 as part of President Biden's omnibus appropriations bill.[10]

Staff

Information on the specific number of staff members at ARPA-H is not detailed in the provided references.

Funding

ARPA-H's funding comes from federal appropriations, with an initial allocation of $6.5 billion requested for three years in the FY 2022 budget proposal, later adjusted to a $1.5 billion commitment.[11]

Services provided

ARPA-H provides funding, support, and a framework for high-risk, high-reward health research projects. It focuses on creating platforms and technologies that can lead to significant health improvements, addressing challenges not met by traditional research or commercial efforts.[12]

Regulations overseen

As ARPA-H is not a regulatory body, it does not directly oversee any regulations but operates within the regulatory environment set by HHS and other federal health agencies.

Headquarters address

The exact address for ARPA-H's headquarters is not publicly listed; however, one of its hubs is located in the Washington metropolitan area.

History

ARPA-H was created to emulate the success of DARPA in defense, bringing a similar approach to health research. The agency was officially established in 2022 with the aim of accelerating medical breakthroughs. The initial director, Renee Wegrzyn, was appointed in 2022.[13]

Creation

ARPA-H was approved by Congress with the passing of H.R. 2471, the Consolidated Appropriations Act, 2022 and was signed into Public Law 117-103 by U.S. President Joe Biden on March 15, 2022.[14] 15 days later Health and Human Services Secretary Xavier Becerra announced that the agency will have access to the resources of the National Institutes of Health, but will answer to the U.S. Secretary of Health and Human Services.[15] The agency initially has a $1 billion budget to be used before fiscal year 2025 (October 2024) and the Biden administration has requested much more funding from Congress. On September 13, 2022, Biden announced his intent to appoint Renee Wegrzyn, formerly of the DARPA biotech office, as the agency's inaugural director, but it is still unknown where its headquarters will be located.[16]

In December 2022, the Consolidated Appropriations Act, 2023 (Pub.L. 117-328) provided $1.5 billion for ARPA-H for fiscal year 2023. The Biden administration requested and received $2.5 billion for FY2024, and had spent $400 million in research grants by August 13, 2024.[17]

In March 2023, ARPA-H announced one of its three headquarters locations would be in the Washington metropolitan area.[18][19] In September 2023, ARPA-H announced that a second hub would be located in Cambridge, Massachusetts following a bid led by U.S. Representative Richard Neal from Massachusetts's 1st congressional district and University of Massachusetts System President Marty Meehan to have the agency locate a hub in the Greater Boston area.[20][21] The third patient engagement-focused hub was established in Dallas, Texas.[22]

History

The Defense Advanced Research Projects Agency (DARPA, formerly ARPA) has been the military's in-house innovator since 1958, a year after the USSR launched Sputnik. DARPA is widely known for creating ARPAnet, the predecessor of the internet, and has been instrumental in advancing hardened electronics, brain-computer interface technology, drones, and stealth technology. Inspired by the success of DARPA, in 2002 the Homeland Security Advanced Research Projects Agency (HSARPA) was created and in 2006 the Intelligence Advanced Research Projects Activity (IARPA) was created. This was followed by the Advanced Research Projects Agency–Energy (ARPA-E) in 2009 and the Advanced Research Projects Agency–Infrastructure (ARPA-I) in 2022. DARPA also inspired the Advanced Research and Invention Agency in the UK and in 2021 the Biden administration proposed ARPA-C for climate research.[23]

The Suzanne Wright Foundation proposed "HARPA" in 2017 to focus on pancreatic cancer and other challenging diseases.[24] A white paper was published by former Obama White House staffers, Michael Stebbins and Geoffrey Ling through the Day One Project that proposed the creation of a new federal agency modeled on DARPA, but focused on health. That proposal was adopted by President Biden's campaign and was the model used for establishing ARPA-H.[25] In June 2021 noted biologists Francis S. Collins (then head of the NIH), Tara Schwetz, Lawrence Tabak, and Eric Lander penned an article in Science supporting the idea.[26] Dr. Collins became an important champion of the idea on Capitol Hill and the legislation garnered numerous sponsors in the 117th Congress.

In September 2022, Renee Wegrzyn was appointed as the agency's inaugural director.[27][28][29]

Research

A White House white paper identifies a number of potential directions for technological development that could occur under the direction of ARPA-H, including cancer vaccines, pandemic preparedness, and prevention technologies, less intrusive wearable blood glucose monitors, and patient-specific T-cell therapies.[30] Additionally, the proposal suggests that ARPA-H focus on platforms to reduce health disparities in maternal morbidity and mortality and improve how medications provided are taken.

One of the first grants from the organization was part of if it’s DIGIHEALS initiative to innovative research that aims to protect the United States health care system against hostile online threats. Christian Dameff and Jeff Tully, medical doctors and medical cybersecurity researchers University of California San Diego School of Medicine, as well as cybersecurity expert Stefan Savage were named investigators to the Healthcare Ransomware Resiliency and Response Program, or H-R3P, project.[31][32]

External links

References

  1. ↑ "Russell Named Acting Deputy Director for New Advanced Research Entity" (in EN). 2022-06-10. https://nihrecord.nih.gov/2022/06/10/russell-named-acting-deputy-director-new-advanced-research-entity. 
  2. ↑ "ARPA-H Mission" (in EN). National Institutes of Health (NIH). 29 June 2021. https://www.nih.gov/arpa-h/mission. 
  3. ↑ "About ARPA-H". Advanced Research Projects Agency for Health. https://www.arpa-h.gov/about. 
  4. ↑ "HHS.gov". U.S. Department of Health and Human Services. https://www.hhs.gov/. 
  5. ↑ "H.R.2471 - Consolidated Appropriations Act, 2022". Congress.gov. https://www.congress.gov/bill/117th-congress/house-bill/2471. 
  6. ↑ "Leadership". Advanced Research Projects Agency for Health. https://www.arpa-h.gov/about/leadership. 
  7. ↑ "Organization". Advanced Research Projects Agency for Health. https://www.arpa-h.gov/about/organization. 
  8. ↑ "DIGIHEALS". Advanced Research Projects Agency for Health. https://www.arpa-h.gov/programs/digiheals. 
  9. ↑ "Sprint for Women's Health". Advanced Research Projects Agency for Health. https://www.arpa-h.gov/programs/sprint-for-womens-health. 
  10. ↑ "Advanced Research Projects Agency for Health (ARPA-H)". The White House. https://www.whitehouse.gov/ostp/news-updates/2021/09/30/advanced-research-projects-agency-for-health-arpa-h/. 
  11. ↑ "Advanced Research Projects Agency for Health (ARPA-H)". The White House. https://www.whitehouse.gov/ostp/news-updates/2021/09/30/advanced-research-projects-agency-for-health-arpa-h/. 
  12. ↑ "About ARPA-H". Advanced Research Projects Agency for Health. https://www.arpa-h.gov/about. 
  13. ↑ "Advanced Research Projects Agency for Health - Wikipedia". https://en.wikipedia.org/wiki/Advanced_Research_Projects_Agency_for_Health. 
  14. ↑ Jeffries, Hakeem S. (15 March 2022). "H.R.2471 - 117th Congress (2021-2022): Consolidated Appropriations Act, 2022". https://www.congress.gov/bill/117th-congress/house-bill/2471.  Division H, Title II. Page 136 STAT. 465 contains relevant passage.
  15. ↑ Mesa, Natalie (1 April 2022). "ARPA-H to Be Within NIH but Independently Managed by HHS" (in en). The Scientist Magazine. https://www.the-scientist.com/news-opinion/arpa-h-to-be-within-nih-but-independently-managed-by-hhs-69862. 
  16. ↑ Kozlov, Max (13 September 2022). "Billion-dollar US health agency gets new chief — but its direction remains in limbo". Nature. https://www.nature.com/articles/d41586-022-02934-y. 
  17. ↑ Tausche, Kayla (August 13, 2024). "With ‘Cancer Moonshot’ announcement, Biden turns to causes most important to him in final months in office". https://edition.cnn.com/2024/08/13/politics/biden-to-highlight-closest-causes-in-final-months-in-office/index.html. 
  18. ↑ Lua error in Module:Citation/CS1/Configuration at line 2088: attempt to index field '?' (a nil value).
  19. ↑ Pub. L. 117–328 (text) (PDF), Division FF, Title II (page 420 of engrossed bill)
  20. ↑ Weisman, Robert; Chesto, Jon (September 26, 2023). "Cambridge picked as a national hub for new federal health research agency". The Boston Globe. https://www.bostonglobe.com/2023/09/26/business/cambridge-arpa-h-hub/. 
  21. ↑ Chesto, Jon (May 16, 2022). "The feds are choosing a headquarters for a federal health research center. Why not pick Boston?". The Boston Globe. https://www.bostonglobe.com/2022/05/16/business/feds-choosing-hq-federal-health-research-center-why-not-boston/. 
  22. ↑ Pandey, Maia (2023-09-26). "Dallas selected as one of three national hubs for new medical innovation federal agency" (in en). https://www.texastribune.org/2023/09/26/dallas-arpha-h-national-hub/. 
  23. ↑ Tollefson, Jeff (22 July 2021). "The rise of 'ARPA-everything' and what it means for science". Nature 595 (7868): 483–484. Bibcode 2021Natur.595..483T. doi:10.1038/d41586-021-01878-z. PMID 34244687. https://www.nature.com/articles/d41586-021-01878-z. 
  24. ↑ "HARPA: Health Advanced Research Projects Agency". The Suzanne Wright Foundation. https://www.harpa.org/. 
  25. ↑ Stebbins, Michael; Ling, Geoffrey (19 April 2020). "Creating the Health Advanced Research Projects Agency (HARPA)". https://www.dayoneproject.org/ideas/creating-the-health-advanced-research-projects-agency-harpa. 
  26. ↑ Collins, Francis S.; Schwetz, Tara A.; Tabak, Lawrence A.; Lander, Eric S. (9 July 2021). "ARPA-H: Accelerating biomedical breakthroughs". Science 373 (6551): 165–167. Bibcode 2021Sci...373..165C. doi:10.1126/science.abj8547. PMID 34244402. 
  27. ↑ "President Biden Announces Intent to Appoint Dr. Renee Wegrzyn as Inaugural Director of Advanced Research Projects Agency for Health (ARPA-H)" (in en-US). 2022-09-12. https://www.whitehouse.gov/briefing-room/statements-releases/2022/09/12/president-biden-announces-intent-to-appoint-dr-renee-wegrzyn-as-inaugural-director-of-advanced-research-projects-agency-for-health-arpa-h/. 
  28. ↑ "DARPA Forward | Dr. Renee Wegrzyn". https://forward.darpa.mil/presenters/Dr_Renee_Wegrzyn. 
  29. ↑ (in en) Biden's new biomedical innovation agency gets its first director. 2022-09-12. doi:10.1126/science.ade8505. https://www.science.org/content/article/biden-s-new-biomedical-innovation-agency-gets-its-first-director. 
  30. ↑ "ARPA-H Frequently Asked Questions". The White House. https://www.whitehouse.gov/wp-content/uploads/2021/09/092921-ARPA-H-FAQ.pdf. 
  31. ↑ "UC San Diego Awarded $9.5 Million to Enhance Cybersecurity in Health Care" (in en). https://today.ucsd.edu/story/uc-san-diego-awarded-9.5-million-to-enhance-cybersecurity-in-health-care. 
  32. ↑ "DIGIHEALS Awardees | ARPA-H" (in en). 2024-07-01. https://arpa-h.gov/explore-funding/programs/digiheals/awardees. 
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