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The Genesis Mission is a United States government initiative established by Executive Order 14363, signed by President Donald Trump on November 24, 2025.[1][2] The program is administered by the Department of Energy (DOE) in coordination with the White House Office of Science and Technology Policy.[3] Its primary objective is to double the productivity and impact of federally funded scientific research and development within a decade through large-scale application of artificial intelligence (AI), high-performance computing, and quantum technologies.[2][4]
The initiative establishes a secure national platform that integrates the DOE’s 17 National Laboratories, exascale supercomputers, and more than 100 petabytes of unique scientific data to train domain-specific AI foundation models and enable closed-loop autonomous experimentation.[3][4]
Background and establishment
The Genesis Mission was formally announced on November 24, 2025.[1][2] It builds on a series of 2025 Trump administration executive actions promoting American AI leadership, including the January 2025 order removing regulatory barriers to AI development and the July 2025 “America’s AI Action Plan.”[2]
Administration officials have described the mission as a response to evidence of declining U.S. scientific productivity since the mid-20th century despite steadily increasing federal R&D investment, citing metrics such as falling rates of new drug approvals and transformative discoveries.[2] The initiative is frequently compared by its proponents to historic national efforts including the Manhattan Project and Apollo program.[3]
Objectives
The mission pursues three overarching national priorities:[2][4]
- Achieving American energy dominance through AI-accelerated development of advanced nuclear fission, fusion energy, and modernized electric grids.
- Advancing fundamental discovery science in fields such as biotechnology, quantum information science, particle physics, and materials discovery.
- Strengthening national security by enhancing nuclear stockpile stewardship without physical testing, reducing reliance on foreign critical materials, and accelerating defense-related materials and manufacturing.
The administration has set an explicit goal of doubling the output and impact of U.S. federal research and development by approximately 2035.[3][4]
Priority research domains
Official documents identify the following priority areas:[2]
- Biotechnology and life sciences
- Critical materials and supply-chain resilience
- Nuclear fission and fusion energy
- Space exploration technologies
- Quantum information science
- Semiconductors and microelectronics
Infrastructure and technical approach
The core element is the “American Science and Security Platform,” a federated, secure infrastructure that combines:[1][4]
- DOE exascale supercomputing systems (Frontier, Aurora, El Capitan, etc.)
- Decades of proprietary experimental and simulation data
- High-throughput scientific instruments and robotic laboratories
- Private-sector AI models and cloud resources under strict government data controls
The platform is designed to support closed-loop scientific loops in which AI systems propose hypotheses, design experiments, interpret results, and iteratively improve models under human supervision.[4]
Leadership and governance
- Lead agency: United States Department of Energy[3]
- Genesis Mission Director: Under Secretary for Science and Innovation Dr. Darío Gil[3]
- Inter-agency coordination: Assistant to the President for Science and Technology Michael Kratsios (as of December 2025)[2]
- National security components: National Nuclear Security Administration[3]
Private-sector partners
As of December 2025, the official Genesis Mission website lists the following industry collaborators:[4]
- Anthropic
- NVIDIA
- OpenAI (government-focused offerings)
- IBM
- Microsoft
- AMD
- Amazon Web Services
- Oracle
Additional partnerships are expected to be announced.[4]
Implementation status
As of December 4, 2025:
- The DOE has mobilized its 17 National Laboratories for rapid stand-up.[3]
- A portfolio of at least 20 high-priority science and technology challenges is in preparation for release in early 2026.[1]
- Secure data-sharing and model-training agreements with industry partners are under negotiation.[4]
- No dedicated congressional appropriation has been enacted; the program currently operates under existing DOE authorities and budgets.[2]
Related initiatives
- American Science and Security Platform (the technical infrastructure created by the mission)
- Proposed GENESIS Act (legislation introduced December 2, 2025 by Rep. Mike Kennedy to codify and fund the mission; not enacted as of December 2025)
References
- ↑ 1.0 1.1 1.2 1.3 "Executive Order: Launching the Genesis Mission". The White House. November 24, 2025. https://www.whitehouse.gov/presidential-actions/2025/11/launching-the-genesis-mission/.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 "Fact Sheet: President Donald J. Trump Unveils the Genesis Mission to Accelerate AI for Scientific Discovery". The White House. November 24, 2025. https://www.whitehouse.gov/fact-sheets/2025/11/fact-sheet-president-donald-j-trump-unveils-the-genesis-missionto-accelerate-ai-for-scientific-discovery/.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 "Energy Department Launches Genesis Mission to Transform American Science and Innovation". U.S. Department of Energy. November 24, 2025. https://www.energy.gov/articles/energy-department-launches-genesis-mission-transform-american-science-and-innovation.
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 "Genesis Mission – Official Website". U.S. Department of Energy. https://genesis.energy.gov/.