CargoAdmin, Bureaucrats, Moderators (CommentStreams), fileuploaders, Interface administrators, newuser, Push subscription managers, Suppressors, Administrators
14,662
edits
Pfizer: Difference between revisions
m
Text replacement - "The Wall Street Journal" to "The Wall Street Journal"
m (Text replacement - "The New York Times" to "The New York Times") |
m (Text replacement - "The Wall Street Journal" to "The Wall Street Journal") |
||
| Line 93: | Line 93: | ||
In 2001, [[Henry McKinnell]] became [[chief executive officer]] of the company, replacing [[William C. Steere, Jr.]]<ref name="longshot">{{Cite news |url=https://www.nytimes.com/2006/07/29/business/29pfizer.html |title=A Long Shot Becomes Pfizer's Latest Chief Executive |first=Alex |last=Berenson |authorlink=Alex Berenson |work=The New York Times |date=July 29, 2006 |url-access=limited}}</ref> | In 2001, [[Henry McKinnell]] became [[chief executive officer]] of the company, replacing [[William C. Steere, Jr.]]<ref name="longshot">{{Cite news |url=https://www.nytimes.com/2006/07/29/business/29pfizer.html |title=A Long Shot Becomes Pfizer's Latest Chief Executive |first=Alex |last=Berenson |authorlink=Alex Berenson |work=The New York Times |date=July 29, 2006 |url-access=limited}}</ref> | ||
In 2002, The [[Bill & Melinda Gates Foundation]] purchased stock in Pfizer.<ref>{{Cite news |last1=Bank |first1=David |last2=Buckman |first2=Rebecca |date=2002-05-17 |title=Gates Foundation Buys Stakes in Drug Makers |work= | In 2002, The [[Bill & Melinda Gates Foundation]] purchased stock in Pfizer.<ref>{{Cite news |last1=Bank |first1=David |last2=Buckman |first2=Rebecca |date=2002-05-17 |title=Gates Foundation Buys Stakes in Drug Makers |work=The Wall Street Journal |url=https://www.wsj.com/articles/SB1021577629748680000 |access-date=2022-06-14 |issn=0099-9660}}</ref> | ||
In 2004, the company received approval for Lyrica ([[pregabalin]]), an [[anticonvulsant]] and [[anxiolytic]] medication used to treat [[epilepsy]], [[neuropathic pain]], [[fibromyalgia]], [[restless leg syndrome]], and [[generalized anxiety disorder]].<ref>{{Cite web |title=Pregabalin |url=https://www.drugs.com/monograph/pregabalin.html |publisher=[[American Society of Health-System Pharmacists]]}}</ref><ref>{{cite journal |last1=Frampton |first1=James E. |title=Pregabalin: A Review of its Use in Adults with Generalized Anxiety Disorder |journal=CNS Drugs |date=September 2014 |volume=28 |issue=9 |pages=835–854 |doi=10.1007/s40263-014-0192-0 |pmid=25149863 |s2cid=5349255}}</ref><ref>{{cite journal |last1=Iftikhar |first1=I. H. |last2=Alghothani |first2=L. |last3=Trotti |first3=L. M. |title=Gabapentin enacarbil, pregabalin and rotigotine are equally effective in restless legs syndrome: a comparative meta-analysis |journal=[[European Journal of Neurology]] |date=December 2017 |volume=24 |issue=12 |pages=1446–1456 |doi=10.1111/ene.13449 |pmid=28888061 |s2cid=22262972}}</ref> The United States patent on Lyrica was challenged by generic manufacturers and was upheld in 2014, extending the expiration date to 2018.<ref>{{Cite news |last=Decker |first=Susan |date=February 6, 2014 |title=Pfizer Wins Ruling to Block Generic Lyrica Until 2018 |work=[[Bloomberg News]] |url=https://www.bloomberg.com/news/2014-02-06/pfizer-wins-ruling-to-block-generic-lyrica-until-2018.html |url-access=subscription}}</ref> | In 2004, the company received approval for Lyrica ([[pregabalin]]), an [[anticonvulsant]] and [[anxiolytic]] medication used to treat [[epilepsy]], [[neuropathic pain]], [[fibromyalgia]], [[restless leg syndrome]], and [[generalized anxiety disorder]].<ref>{{Cite web |title=Pregabalin |url=https://www.drugs.com/monograph/pregabalin.html |publisher=[[American Society of Health-System Pharmacists]]}}</ref><ref>{{cite journal |last1=Frampton |first1=James E. |title=Pregabalin: A Review of its Use in Adults with Generalized Anxiety Disorder |journal=CNS Drugs |date=September 2014 |volume=28 |issue=9 |pages=835–854 |doi=10.1007/s40263-014-0192-0 |pmid=25149863 |s2cid=5349255}}</ref><ref>{{cite journal |last1=Iftikhar |first1=I. H. |last2=Alghothani |first2=L. |last3=Trotti |first3=L. M. |title=Gabapentin enacarbil, pregabalin and rotigotine are equally effective in restless legs syndrome: a comparative meta-analysis |journal=[[European Journal of Neurology]] |date=December 2017 |volume=24 |issue=12 |pages=1446–1456 |doi=10.1111/ene.13449 |pmid=28888061 |s2cid=22262972}}</ref> The United States patent on Lyrica was challenged by generic manufacturers and was upheld in 2014, extending the expiration date to 2018.<ref>{{Cite news |last=Decker |first=Susan |date=February 6, 2014 |title=Pfizer Wins Ruling to Block Generic Lyrica Until 2018 |work=[[Bloomberg News]] |url=https://www.bloomberg.com/news/2014-02-06/pfizer-wins-ruling-to-block-generic-lyrica-until-2018.html |url-access=subscription}}</ref> | ||
| Line 106: | Line 106: | ||
==== Acquisitions and mergers ==== | ==== Acquisitions and mergers ==== | ||
In June 2000, Pfizer acquired Warner-Lambert outright for $116{{nbsp}}billion. To satisfy conditions imposed by antitrust regulators at the [[Federal Trade Commission]], Pfizer sold off or transferred stakes in several minor products, including RID (a shampoo for treatment of [[Head lice infestation|head lice]], sold to [[Bayer]]) and Warner-Lambert's antidepressant [[Celexa]] (which competes with Zoloft).<ref>{{Cite news |last=Hensley |first=Scott |date=June 20, 2000 |title=Pfizer Completes Stormy Takeover Of Warner-Lambert for $116 Billion |work= | In June 2000, Pfizer acquired Warner-Lambert outright for $116{{nbsp}}billion. To satisfy conditions imposed by antitrust regulators at the [[Federal Trade Commission]], Pfizer sold off or transferred stakes in several minor products, including RID (a shampoo for treatment of [[Head lice infestation|head lice]], sold to [[Bayer]]) and Warner-Lambert's antidepressant [[Celexa]] (which competes with Zoloft).<ref>{{Cite news |last=Hensley |first=Scott |date=June 20, 2000 |title=Pfizer Completes Stormy Takeover Of Warner-Lambert for $116 Billion |work=The Wall Street Journal |url=https://www.wsj.com/articles/SB961456765639278103 |url-access=subscription}}</ref> The acquisition created what was, at the time, the second-largest pharmaceutical company worldwide.<ref>{{Cite news |last=Campbell |first=Todd |date=May 15, 2017 |title=Here are the 7 biggest mergers of all time |publisher=[[Business Insider]] |agency=[[The Motley Fool]] |url=https://www.businessinsider.com/here-are-the-7-biggest-mergers-of-all-time-2017-5#6-warner-lambert-warms-up-to-pfizer-89-billion-2}}</ref> | ||
In 2003, Pfizer merged with [[Pharmacia]], and in the process acquired [[G.D. Searle, LLC|Searle]] and [[SUGEN]]. Searle had developed Flagyl ([[metronidazole]]), a [[nitroimidazole]] antibiotic medication used particularly for [[anaerobe|anaerobic]] [[bacterium|bacteria]] and [[protozoa]].<ref name=":0" /><ref>{{Cite web |title=Metronidazole Monograph for Professionals |url=https://www.drugs.com/monograph/metronidazole.html |publisher=[[Drugs.com]]}}</ref> Searle also developed [[celecoxib]] (Celebrex) a [[COX-2 inhibitor]] and [[nonsteroidal anti-inflammatory drug]] (NSAID) used to treat the [[pain]] and [[inflammation]] in [[osteoarthritis]], [[acute pain]] in adults, [[rheumatoid arthritis]], [[ankylosing spondylitis]], [[painful menstruation]], and [[juvenile rheumatoid arthritis]].<ref>{{cite web |date=11 November 2019 |title=Celecoxib Monograph for Professionals |url=https://www.drugs.com/monograph/celecoxib.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists}}</ref> [[SUGEN]], a company focused on [[protein kinase]] inhibitors, had pioneered the use of ATP-mimetic small molecules to block [[signal transduction]]. The [[SUGEN]] facility was shut down in 2003 by Pfizer, with the loss of more than 300 jobs, and several programs were transferred to Pfizer. These included [[sunitinib]] (Sutent), a cancer medication which was approved for human use by the FDA in January 2006.<ref>{{Cite news |url=https://www.bloomberg.com/news/articles/2005-11-20/the-spirit-of-a-startup-lives-on |title=The Spirit Of A Startup Lives On |work=[[Bloomberg Businessweek]] |date=November 21, 2005}}</ref><ref>{{Cite news |url=https://www.bizjournals.com/sanfrancisco/stories/2003/04/28/daily24.html |title=Pfizer expects to shutter South City biotech outpost |work=[[American City Business Journals]] |date=April 30, 2003}}</ref> A related compound, SU11654 ([[Toceranib]]), was also approved for [[cancer in dogs]], and the [[ALK inhibitor]] [[Crizotinib]] also grew out of a SUGEN program.<ref>{{Cite news |url=https://www.wsj.com/articles/SB10001424053111904009304576532892704206326 |title=FDA Approves Pfizer Lung-Cancer Drug |first=Jonathan D. |last=Rockoff |work= | In 2003, Pfizer merged with [[Pharmacia]], and in the process acquired [[G.D. Searle, LLC|Searle]] and [[SUGEN]]. Searle had developed Flagyl ([[metronidazole]]), a [[nitroimidazole]] antibiotic medication used particularly for [[anaerobe|anaerobic]] [[bacterium|bacteria]] and [[protozoa]].<ref name=":0" /><ref>{{Cite web |title=Metronidazole Monograph for Professionals |url=https://www.drugs.com/monograph/metronidazole.html |publisher=[[Drugs.com]]}}</ref> Searle also developed [[celecoxib]] (Celebrex) a [[COX-2 inhibitor]] and [[nonsteroidal anti-inflammatory drug]] (NSAID) used to treat the [[pain]] and [[inflammation]] in [[osteoarthritis]], [[acute pain]] in adults, [[rheumatoid arthritis]], [[ankylosing spondylitis]], [[painful menstruation]], and [[juvenile rheumatoid arthritis]].<ref>{{cite web |date=11 November 2019 |title=Celecoxib Monograph for Professionals |url=https://www.drugs.com/monograph/celecoxib.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists}}</ref> [[SUGEN]], a company focused on [[protein kinase]] inhibitors, had pioneered the use of ATP-mimetic small molecules to block [[signal transduction]]. The [[SUGEN]] facility was shut down in 2003 by Pfizer, with the loss of more than 300 jobs, and several programs were transferred to Pfizer. These included [[sunitinib]] (Sutent), a cancer medication which was approved for human use by the FDA in January 2006.<ref>{{Cite news |url=https://www.bloomberg.com/news/articles/2005-11-20/the-spirit-of-a-startup-lives-on |title=The Spirit Of A Startup Lives On |work=[[Bloomberg Businessweek]] |date=November 21, 2005}}</ref><ref>{{Cite news |url=https://www.bizjournals.com/sanfrancisco/stories/2003/04/28/daily24.html |title=Pfizer expects to shutter South City biotech outpost |work=[[American City Business Journals]] |date=April 30, 2003}}</ref> A related compound, SU11654 ([[Toceranib]]), was also approved for [[cancer in dogs]], and the [[ALK inhibitor]] [[Crizotinib]] also grew out of a SUGEN program.<ref>{{Cite news |url=https://www.wsj.com/articles/SB10001424053111904009304576532892704206326 |title=FDA Approves Pfizer Lung-Cancer Drug |first=Jonathan D. |last=Rockoff |work=The Wall Street Journal |date=August 26, 2011 |url-access=subscription}}</ref><ref>{{cite book |doi=10.1016/B978-0-12-409547-2.12391-1 |chapter=Selective Kinase Inhibitors in Cancer |title=Comprehensive Medicinal Chemistry III |year=2017 |last1=Mortlock |first1=A.A. |last2=Wilson |first2=D.M. |last3=Kettle |first3=J.G. |last4=Goldberg |first4=F.W. |last5=Foote |first5=K.M. |pages=39–75 |isbn=978-0-12-803201-5}}</ref> | ||
In October 2006, the company announced it would acquire PowerMed.<ref>{{Cite news |last=Barriaux |first=Marianne |date=October 9, 2006 |title=Pfizer buys vaccine developer PowderMed |work=[[The Guardian]] |url=https://www.theguardian.com/business/2006/oct/09/money5}}</ref> | In October 2006, the company announced it would acquire PowerMed.<ref>{{Cite news |last=Barriaux |first=Marianne |date=October 9, 2006 |title=Pfizer buys vaccine developer PowderMed |work=[[The Guardian]] |url=https://www.theguardian.com/business/2006/oct/09/money5}}</ref> | ||
On October 15, 2009, Pfizer acquired [[Wyeth]] for $68{{nbsp}}billion in cash and stock, including the assumption of debt, making Pfizer the largest pharmaceutical company in the world.<ref>{{Cite news |last1=Sorkin |first1=Andrew Ross |last2=Wilson |first2=Duff |date=January 25, 2009 |title=Pfizer Agrees to Pay $68 Billion for Rival Drug Maker Wyeth |work=The New York Times |url=https://www.nytimes.com/2009/01/26/business/26drug.html |url-access=limited |issn=0362-4331 |authorlink1=Andrew Ross Sorkin |authorlink2=Duff Wilson}}</ref><ref>{{Cite news |date=October 15, 2009 |title=Pfizer completes $67 billion deal for rival Wyeth |work=[[Reuters]] |url=https://www.reuters.com/article/instant-article/idUSTRE59E4S320091015}}</ref><ref>{{cite news |last1=Karnitschnig |first1=Matthew |last2=Rockoff |first2=Jonathan D. |date=January 23, 2009 |title=Pfizer in Talks to Buy Wyeth |work= | On October 15, 2009, Pfizer acquired [[Wyeth]] for $68{{nbsp}}billion in cash and stock, including the assumption of debt, making Pfizer the largest pharmaceutical company in the world.<ref>{{Cite news |last1=Sorkin |first1=Andrew Ross |last2=Wilson |first2=Duff |date=January 25, 2009 |title=Pfizer Agrees to Pay $68 Billion for Rival Drug Maker Wyeth |work=The New York Times |url=https://www.nytimes.com/2009/01/26/business/26drug.html |url-access=limited |issn=0362-4331 |authorlink1=Andrew Ross Sorkin |authorlink2=Duff Wilson}}</ref><ref>{{Cite news |date=October 15, 2009 |title=Pfizer completes $67 billion deal for rival Wyeth |work=[[Reuters]] |url=https://www.reuters.com/article/instant-article/idUSTRE59E4S320091015}}</ref><ref>{{cite news |last1=Karnitschnig |first1=Matthew |last2=Rockoff |first2=Jonathan D. |date=January 23, 2009 |title=Pfizer in Talks to Buy Wyeth |work=The Wall Street Journal |url=https://www.wsj.com/articles/SB123268511212809429 |url-access=subscription}}</ref><ref name="worst">{{Cite news |last=Edwards |first=Jim |date=January 23, 2009 |title=The Pfizer–Wyeth Deal Worst-Case Scenario |work=[[CBS News]] |url=https://www.cbsnews.com/news/the-pfizer-wyeth-deal-worst-case-scenario/}}</ref><ref name="wyethpr">{{Cite press release |title=PFIZER COMPLETES ACQUISITION OF WYETH |url=https://www.pfizer.com/news/press-release/press-release-detail/pfizer_completes_acquisition_of_wyeth |publisher=Pfizer |date=October 14, 2009}}</ref> The acquisition of Wyeth provided Pfizer with a [[pneumococcal conjugate vaccine]], trademarked [[Pneumococcal conjugate vaccine#Prevnar|Prevnar 13]]; this is used for the prevention of invasive pneumococcal infections. The introduction of the original, 7-valent version of the vaccine, developed by [[Wyeth]] in February 2000, led to a 75% reduction in the incidence of invasive pneumococcal infections among children under age{{nbsp}}5 in the United States. Pfizer introduced an improved version of the vaccine in 2010, for which it was granted a patent in India in 2017. Prevnar 13 provides coverage of 13 bacterial variants, expanding beyond the original 7-valent version.<ref name="wyethpr" /> By 2012, the rate of invasive infections among children under age{{spaces}}5 had been reduced by an additional 50%.<ref name="cdc.gov">{{Cite web |date=April 5, 2019 |title=CDC – ABCs: Surveillance Reports main page – Active Bacterial Core surveillance |url=https://www.cdc.gov/abcs/reports-findings/surv-reports.html}}</ref><ref>{{Cite web |last=Herper |first=Matthew |date=August 24, 2020 |title=In the race for a Covid-19 vaccine, Pfizer turns to a scientist with a history of defying skeptics – and getting results |url=https://www.statnews.com/2020/08/24/pfizer-edge-in-the-race-for-a-covid-19-vaccine-could-be-a-scientist-with-two-best-sellers-to-her-credit/ |website=[[Stat (website)|Stat]]}}</ref> | ||
=== 2010–2020: Further discoveries and acquisitions === | === 2010–2020: Further discoveries and acquisitions === | ||
| Line 122: | Line 122: | ||
On September 4, 2012, the FDA approved [[bosutinib]] (Bosulif) for [[chronic myelogenous leukemia]] (CML), a rare type of [[leukemia]] and a blood and [[bone marrow]] disease that affects primarily older adults.<ref>{{Cite news |url=https://www.reuters.com/article/us-pfizer-leukemia/fda-approves-pfizer-leukemia-drug-idUSBRE88314720120904 |title=FDA approves Pfizer leukemia drug |first=Anna |last=Yukhananov |work=[[Reuters]] |date=September 4, 2012}}</ref> In November 2012, Pfizer received approval from the [[Food and Drug Administration]] for Xeljanz, a [[tofacitinib]], for [[rheumatoid arthritis]] and [[ulcerative colitis]].<ref>{{Cite web |url=https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214orig1s000toc.cfm |title=Drug Approval Package |publisher=[[Food and Drug Administration]]}}</ref> The drug had sales of $1.77{{nbsp}}billion in 2018, and in January 2019, it was the top drug in the United States for [[direct-to-consumer advertising]], passing [[adalimumab]] (Humira).<ref>{{Cite magazine |title=Pfizer switches RA patients to lower dose of fast-growing Xeljanz as safety issues arise in postmarketing study |url=https://www.fiercepharma.com/pharma/postmarketing-study-pfizer-switches-ra-patients-to-lower-xeljanz-dose-safety-concerns |magazine=Fierce Pharma |first=Eric |last=Sagonowsky |date=February 20, 2019}}</ref> | On September 4, 2012, the FDA approved [[bosutinib]] (Bosulif) for [[chronic myelogenous leukemia]] (CML), a rare type of [[leukemia]] and a blood and [[bone marrow]] disease that affects primarily older adults.<ref>{{Cite news |url=https://www.reuters.com/article/us-pfizer-leukemia/fda-approves-pfizer-leukemia-drug-idUSBRE88314720120904 |title=FDA approves Pfizer leukemia drug |first=Anna |last=Yukhananov |work=[[Reuters]] |date=September 4, 2012}}</ref> In November 2012, Pfizer received approval from the [[Food and Drug Administration]] for Xeljanz, a [[tofacitinib]], for [[rheumatoid arthritis]] and [[ulcerative colitis]].<ref>{{Cite web |url=https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214orig1s000toc.cfm |title=Drug Approval Package |publisher=[[Food and Drug Administration]]}}</ref> The drug had sales of $1.77{{nbsp}}billion in 2018, and in January 2019, it was the top drug in the United States for [[direct-to-consumer advertising]], passing [[adalimumab]] (Humira).<ref>{{Cite magazine |title=Pfizer switches RA patients to lower dose of fast-growing Xeljanz as safety issues arise in postmarketing study |url=https://www.fiercepharma.com/pharma/postmarketing-study-pfizer-switches-ra-patients-to-lower-xeljanz-dose-safety-concerns |magazine=Fierce Pharma |first=Eric |last=Sagonowsky |date=February 20, 2019}}</ref> | ||
On February 1, 2013, [[Zoetis]], the Agriculture Division of Pfizer and later Pfizer Animal Health, became a [[public company]] via an [[initial public offering]], raising $2.2{{nbsp}}billion.<ref>{{Cite press release |title=Zoetis™ Files IPO Registration Statement |url=https://www.zoetisus.com/news-and-media/zoetis-files-ipo-registration-statement.aspx |publisher=[[Business Wire]] |date=August 13, 2012}}</ref><ref>{{Cite news |url=https://dealbook.nytimes.com/2013/02/01/shares-of-zoetis-surge-on-debut/ |last=J. de la Merced |first=Michael |title=Shares of Zoetis Surge on Debut |work=The New York Times |date=February 1, 2013 |url-access=limited}}</ref><ref>{{Cite news |title=Zoetis Raises $2.2 Billion in IPO |url=https://www.wsj.com/articles/SB10001424127887323701904578276530830057770 |last=Dieterich |first=Chris |work= | On February 1, 2013, [[Zoetis]], the Agriculture Division of Pfizer and later Pfizer Animal Health, became a [[public company]] via an [[initial public offering]], raising $2.2{{nbsp}}billion.<ref>{{Cite press release |title=Zoetis™ Files IPO Registration Statement |url=https://www.zoetisus.com/news-and-media/zoetis-files-ipo-registration-statement.aspx |publisher=[[Business Wire]] |date=August 13, 2012}}</ref><ref>{{Cite news |url=https://dealbook.nytimes.com/2013/02/01/shares-of-zoetis-surge-on-debut/ |last=J. de la Merced |first=Michael |title=Shares of Zoetis Surge on Debut |work=The New York Times |date=February 1, 2013 |url-access=limited}}</ref><ref>{{Cite news |title=Zoetis Raises $2.2 Billion in IPO |url=https://www.wsj.com/articles/SB10001424127887323701904578276530830057770 |last=Dieterich |first=Chris |work=The Wall Street Journal |date=January 31, 2013 |url-access=subscription}}</ref><ref>{{Cite news |url=https://www.cbsnews.com/news/shares-of-animal-health-company-zoetis-soar-in-ipo/ |title=Shares of animal health company Zoetis soar in IPO |agency=[[Associated Press]] |publisher=[[CBS News]] |date=February 1, 2013}}</ref> Later in 2013, Pfizer completed the [[corporate spin-off]] of its remaining stake in [[Zoetis]].<ref>{{Cite news |url=https://www.wsj.com/articles/SB10001424127887323975004578498994013821124 |title=Pfizer to Spin Off Remaining Zoetis Stake |first=Peter |last=Loftus |work=The Wall Street Journal |date=May 22, 2013}}</ref><ref>{{Cite news |url=https://www.reuters.com/article/us-pfizer-zoetis/pfizer-to-spin-off-zoetis-stake-to-shareholders-idUSBRE94L0JB20130522 |title=Pfizer to spin off Zoetis stake to shareholders |first1=Caroline |last1=Humer |first2=Ransdell |last2=Pierson |work=[[Reuters]] |date=May 22, 2013}}</ref> | ||
In September 2014, the company acquired Innopharma for $225{{nbsp}}million, plus up to $135{{nbsp}}million in milestone payments, in a deal that expanded Pfizer's range of generic and injectable drugs.<ref>{{Cite magazine |url=https://www.fiercepharma.com/pharma/pfizer-completes-acquisition-of-innopharma |title=Pfizer Completes Acquisition Of InnoPharma |first=Emily |last=Wasserman |magazine=Fierce Pharma |date=September 29, 2014}}</ref><ref>{{Cite news |title=Pfizer to Acquire InnoPharma for Up to $360M |url=https://www.genengnews.com/news/pfizer-to-acquire-innopharma-for-up-to-360m/ |website=genengnews.com |date=July 16, 2014}}</ref> | In September 2014, the company acquired Innopharma for $225{{nbsp}}million, plus up to $135{{nbsp}}million in milestone payments, in a deal that expanded Pfizer's range of generic and injectable drugs.<ref>{{Cite magazine |url=https://www.fiercepharma.com/pharma/pfizer-completes-acquisition-of-innopharma |title=Pfizer Completes Acquisition Of InnoPharma |first=Emily |last=Wasserman |magazine=Fierce Pharma |date=September 29, 2014}}</ref><ref>{{Cite news |title=Pfizer to Acquire InnoPharma for Up to $360M |url=https://www.genengnews.com/news/pfizer-to-acquire-innopharma-for-up-to-360m/ |website=genengnews.com |date=July 16, 2014}}</ref> | ||
| Line 130: | Line 130: | ||
In June 2016, the company acquired Anacor Pharmaceuticals for $5.2{{nbsp}}billion, expanding its portfolio in both inflammation and immunology drugs areas.<ref>{{cite press release |url=https://www.businesswire.com/news/home/20160624005299/en/Pfizer-Completes-Acquisition-of-Anacor |title=Pfizer Completes Acquisition of Anacor |publisher=Pfizer |via=[[Business Wire]] |date=June 24, 2016}}</ref><ref>{{Cite news |title=Pfizer to Acquire Anacor Pharmaceuticals for $5.2B |url=https://www.genengnews.com/news/pfizer-to-acquire-anacor-pharmaceuticals-for-5-2b/ |website=genengnews.com |date=May 16, 2016}}</ref> In August 2016, the company made a $40{{nbsp}}million bid for the assets of BIND Therapeutics, which was in [[bankruptcy]].<ref>{{Cite news |title=Pfizer Places High Bid of $40M for BIND Therapeutics |url=https://www.genengnews.com/news/pfizer-places-high-bid-of-40m-for-bind-therapeutics/ |website=genengnews.com |date=July 27, 2016}}</ref> The same month, the company acquired Bamboo Therapeutics for $645{{nbsp}}million, expanding its gene therapy offerings.<ref>{{Cite news |title=Pfizer Acquires Bamboo Therapeutics in a $645M Deal |url=https://www.genengnews.com/news/pfizer-acquires-bamboo-therapeutics-in-a-645m-deal/ |website=genengnews.com |date=August 1, 2016}}</ref> In September 2016, the company acquired cancer drug-maker [[Medivation]] for $14{{nbsp}}billion.<ref>{{Cite news |title=Pfizer to Acquire Medivation for $14B |url=https://www.genengnews.com/news/pfizer-to-acquire-medivation-for-14b/ |website=genengnews.com |date=August 22, 2016}}</ref><ref>{{Cite news |title=Pfizer to buy cancer drug firm Medivation for $14bn |work=[[BBC News]] |url=https://www.bbc.co.uk/news/business-37150531 |date=August 22, 2016}}</ref><ref>{{Cite press release |url=https://www.businesswire.com/news/home/20160928005824/en/ |title=Pfizer Completes Acquisition of Medivation |publisher=OncoImmune |via=[[Business Wire]] |date=September 28, 2016}}</ref> In October 2016, the company licensed the anti-[[CTLA4]] monoclonal antibody, ONC-392, from OncoImmune.<ref>{{Cite news |url=https://www.genengnews.com/topics/drug-discovery/oncoimmune-licenses-onc-392-to-pfizer-for-up-to-250m/ |title=OncoImmune Licenses ONC-392 to Pfizer for Up to $250M |work=genengnews.com |date=October 15, 2016}}</ref><ref>{{cite press release |url=https://www.businesswire.com/news/home/20160915005151/en/OncoImmune-Announces-Option-and-License-Agreement-with-Pfizer-Inc. |title=OncoImmune Announces Option and License Agreement with Pfizer Inc. |publisher=Pfizer |via=[[Business Wire]] |date=September 15, 2016}}</ref> In November 2016, Pfizer funded a $3,435,600 study with the [[CDC Foundation]] to research "screen-and-treat" strategies for [[cryptococcal disease]] in [[Botswana]].<ref name=":4">{{Cite web |date=2021-12-09 |title=CDC Foundation Active Programs October 1, 2020 – September 30, 2021 |url=https://www.cdcfoundation.org/CDCF-ActivePrograms-CDC-FY21?inline |url-status=live |archive-url=https://web.archive.org/web/20220115161004/https://www.cdcfoundation.org/CDCF-ActivePrograms-CDC-FY21?inline |archive-date=2022-01-15 |access-date=2022-08-06 |website=[[CDC Foundation]]}}</ref> In December 2016, Pfizer acquired [[AstraZeneca]]'s small-molecule antibiotics business for $1.575 billion.<ref>{{Cite press release |url=https://www.businesswire.com/news/home/20161222005395/en/Pfizer-Completes-Acquisition-of-Small-Molecule-Anti-Infective-Business-From-AstraZeneca |title=Pfizer Completes Acquisition of Small Molecule Anti-Infective Business From AstraZeneca |publisher=Pfizer |via=[[Business Wire]] |date=December 23, 2016}}</ref><ref>{{Cite news |title=Pfizer Buys AstraZeneca Antibiotics for Up to $1.575B |url=https://www.genengnews.com/topics/drug-discovery/pfizer-buys-astrazeneca-antibiotics-for-up-to-1-575b/ |website=genengnews.com |date=August 24, 2016}}</ref><ref>{{Cite magazine |title=Pfizer grabs AZ antibiotics in $1.5B deal. Pre-split prep or just another sales-boosting buy? |url=https://www.fiercepharma.com/pharma/pfizer-grabs-az-antibiotics-1-5b-deal-pre-split-prep-or-just-another-sales-boosting-buy |first=Tracy |last=Staton |magazine=Fierce Pharma |date=August 24, 2016}}</ref> | In June 2016, the company acquired Anacor Pharmaceuticals for $5.2{{nbsp}}billion, expanding its portfolio in both inflammation and immunology drugs areas.<ref>{{cite press release |url=https://www.businesswire.com/news/home/20160624005299/en/Pfizer-Completes-Acquisition-of-Anacor |title=Pfizer Completes Acquisition of Anacor |publisher=Pfizer |via=[[Business Wire]] |date=June 24, 2016}}</ref><ref>{{Cite news |title=Pfizer to Acquire Anacor Pharmaceuticals for $5.2B |url=https://www.genengnews.com/news/pfizer-to-acquire-anacor-pharmaceuticals-for-5-2b/ |website=genengnews.com |date=May 16, 2016}}</ref> In August 2016, the company made a $40{{nbsp}}million bid for the assets of BIND Therapeutics, which was in [[bankruptcy]].<ref>{{Cite news |title=Pfizer Places High Bid of $40M for BIND Therapeutics |url=https://www.genengnews.com/news/pfizer-places-high-bid-of-40m-for-bind-therapeutics/ |website=genengnews.com |date=July 27, 2016}}</ref> The same month, the company acquired Bamboo Therapeutics for $645{{nbsp}}million, expanding its gene therapy offerings.<ref>{{Cite news |title=Pfizer Acquires Bamboo Therapeutics in a $645M Deal |url=https://www.genengnews.com/news/pfizer-acquires-bamboo-therapeutics-in-a-645m-deal/ |website=genengnews.com |date=August 1, 2016}}</ref> In September 2016, the company acquired cancer drug-maker [[Medivation]] for $14{{nbsp}}billion.<ref>{{Cite news |title=Pfizer to Acquire Medivation for $14B |url=https://www.genengnews.com/news/pfizer-to-acquire-medivation-for-14b/ |website=genengnews.com |date=August 22, 2016}}</ref><ref>{{Cite news |title=Pfizer to buy cancer drug firm Medivation for $14bn |work=[[BBC News]] |url=https://www.bbc.co.uk/news/business-37150531 |date=August 22, 2016}}</ref><ref>{{Cite press release |url=https://www.businesswire.com/news/home/20160928005824/en/ |title=Pfizer Completes Acquisition of Medivation |publisher=OncoImmune |via=[[Business Wire]] |date=September 28, 2016}}</ref> In October 2016, the company licensed the anti-[[CTLA4]] monoclonal antibody, ONC-392, from OncoImmune.<ref>{{Cite news |url=https://www.genengnews.com/topics/drug-discovery/oncoimmune-licenses-onc-392-to-pfizer-for-up-to-250m/ |title=OncoImmune Licenses ONC-392 to Pfizer for Up to $250M |work=genengnews.com |date=October 15, 2016}}</ref><ref>{{cite press release |url=https://www.businesswire.com/news/home/20160915005151/en/OncoImmune-Announces-Option-and-License-Agreement-with-Pfizer-Inc. |title=OncoImmune Announces Option and License Agreement with Pfizer Inc. |publisher=Pfizer |via=[[Business Wire]] |date=September 15, 2016}}</ref> In November 2016, Pfizer funded a $3,435,600 study with the [[CDC Foundation]] to research "screen-and-treat" strategies for [[cryptococcal disease]] in [[Botswana]].<ref name=":4">{{Cite web |date=2021-12-09 |title=CDC Foundation Active Programs October 1, 2020 – September 30, 2021 |url=https://www.cdcfoundation.org/CDCF-ActivePrograms-CDC-FY21?inline |url-status=live |archive-url=https://web.archive.org/web/20220115161004/https://www.cdcfoundation.org/CDCF-ActivePrograms-CDC-FY21?inline |archive-date=2022-01-15 |access-date=2022-08-06 |website=[[CDC Foundation]]}}</ref> In December 2016, Pfizer acquired [[AstraZeneca]]'s small-molecule antibiotics business for $1.575 billion.<ref>{{Cite press release |url=https://www.businesswire.com/news/home/20161222005395/en/Pfizer-Completes-Acquisition-of-Small-Molecule-Anti-Infective-Business-From-AstraZeneca |title=Pfizer Completes Acquisition of Small Molecule Anti-Infective Business From AstraZeneca |publisher=Pfizer |via=[[Business Wire]] |date=December 23, 2016}}</ref><ref>{{Cite news |title=Pfizer Buys AstraZeneca Antibiotics for Up to $1.575B |url=https://www.genengnews.com/topics/drug-discovery/pfizer-buys-astrazeneca-antibiotics-for-up-to-1-575b/ |website=genengnews.com |date=August 24, 2016}}</ref><ref>{{Cite magazine |title=Pfizer grabs AZ antibiotics in $1.5B deal. Pre-split prep or just another sales-boosting buy? |url=https://www.fiercepharma.com/pharma/pfizer-grabs-az-antibiotics-1-5b-deal-pre-split-prep-or-just-another-sales-boosting-buy |first=Tracy |last=Staton |magazine=Fierce Pharma |date=August 24, 2016}}</ref> | ||
In January 2018, Pfizer announced that it would end its work on research into treatments for [[Alzheimer's disease]] and [[Parkinsonism]] (a symptom of [[Parkinson's disease]] and other conditions). The company said about 300 researchers would lose their jobs.<ref>{{Cite news |last=Hiltzik |first=Michael | author-link=Michael Hiltzik |title=Pfizer, pocketing a big tax cut from Trump, will end investment in Alzheimer's and Parkinson's research |url=https://www.latimes.com/business/hiltzik/la-fi-hiltzik-pfizer-20180108-story.html |work=[[Los Angeles Times]] |date=January 8, 2018 |url-access=subscription}}</ref> In July 2018, the [[Food and Drug Administration]] approved [[enzalutamide]], developed by Pfizer and [[Astellas Pharma]] for patients with [[castration]]-resistant [[prostate cancer]].<ref>{{Cite press release |url=https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-enzalutamide-castration-resistant-prostate-cancer |title=FDA approves enzalutamide for castration-resistant prostate cancer |publisher=[[Food and Drug Administration]] |date=July 13, 2018}}</ref> In August 2018, Pfizer signed an agreement with [[BioNTech]] to conduct joint research and development activities regarding [[mRNA]]-based [[influenza vaccine]]s.<ref>{{Cite press release |title=BioNTech Signs Collaboration Agreement with Pfizer to Develop mRNA-based Vaccines for Prevention of Influenza |url=https://biontechse.gcs-web.com/news-releases/news-release-details/biontech-signs-collaboration-agreement-pfizer-develop-mrna-based |publisher=[[BioNTech]] |date=August 16, 2018}}</ref> In October 2018, effective January 1, 2019, [[Albert Bourla]] was promoted to [[chief executive officer]], succeeding [[Ian Read]], his mentor.<ref>{{Cite news |url=https://www.reuters.com/article/us-pfizer-ceo/pfizer-to-replace-longtime-ceo-read-with-veteran-bourla-idUSKCN1MB29D |title=Pfizer to replace longtime CEO Read with veteran Bourla |first1=Tamara |last1=Mathias |first2=Ankur |last2=Banerjee |date=October 1, 2018 |work=[[Reuters]]}}</ref><ref>{{cite news |last=Maidenberg |first=Micah |title=Pfizer Prepares for CEO Transition With Executive Suite Changes |url=https://www.wsj.com/articles/pfizer-prepares-for-ceo-transition-with-executive-suite-changes-1539095075 |work= | In January 2018, Pfizer announced that it would end its work on research into treatments for [[Alzheimer's disease]] and [[Parkinsonism]] (a symptom of [[Parkinson's disease]] and other conditions). The company said about 300 researchers would lose their jobs.<ref>{{Cite news |last=Hiltzik |first=Michael | author-link=Michael Hiltzik |title=Pfizer, pocketing a big tax cut from Trump, will end investment in Alzheimer's and Parkinson's research |url=https://www.latimes.com/business/hiltzik/la-fi-hiltzik-pfizer-20180108-story.html |work=[[Los Angeles Times]] |date=January 8, 2018 |url-access=subscription}}</ref> In July 2018, the [[Food and Drug Administration]] approved [[enzalutamide]], developed by Pfizer and [[Astellas Pharma]] for patients with [[castration]]-resistant [[prostate cancer]].<ref>{{Cite press release |url=https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-enzalutamide-castration-resistant-prostate-cancer |title=FDA approves enzalutamide for castration-resistant prostate cancer |publisher=[[Food and Drug Administration]] |date=July 13, 2018}}</ref> In August 2018, Pfizer signed an agreement with [[BioNTech]] to conduct joint research and development activities regarding [[mRNA]]-based [[influenza vaccine]]s.<ref>{{Cite press release |title=BioNTech Signs Collaboration Agreement with Pfizer to Develop mRNA-based Vaccines for Prevention of Influenza |url=https://biontechse.gcs-web.com/news-releases/news-release-details/biontech-signs-collaboration-agreement-pfizer-develop-mrna-based |publisher=[[BioNTech]] |date=August 16, 2018}}</ref> In October 2018, effective January 1, 2019, [[Albert Bourla]] was promoted to [[chief executive officer]], succeeding [[Ian Read]], his mentor.<ref>{{Cite news |url=https://www.reuters.com/article/us-pfizer-ceo/pfizer-to-replace-longtime-ceo-read-with-veteran-bourla-idUSKCN1MB29D |title=Pfizer to replace longtime CEO Read with veteran Bourla |first1=Tamara |last1=Mathias |first2=Ankur |last2=Banerjee |date=October 1, 2018 |work=[[Reuters]]}}</ref><ref>{{cite news |last=Maidenberg |first=Micah |title=Pfizer Prepares for CEO Transition With Executive Suite Changes |url=https://www.wsj.com/articles/pfizer-prepares-for-ceo-transition-with-executive-suite-changes-1539095075 |work=The Wall Street Journal |date=October 9, 2018 |url-access=subscription}}</ref><ref>{{cite news |url=https://www.businessinsider.com/who-is-albert-bourla-next-pfizer-ceo-2018-10 |title=Pfizer's CEO is stepping down after 8 years — meet the man who will be replacing him |last=Ramsey |first=Lydia |work=[[Business Insider]] |date=October 1, 2018 |url-access=subscription}}</ref><ref>{{cite news |last=Jarvis |first=Lisa M. |title=Pfizer unveils CEO succession plan |work=[[Chemical & Engineering News]] |url=https://cen.acs.org/pharmaceuticals/Pfizer-unveils-CEO-succession-plan/96/i40 |date=October 3, 2018}}</ref> | ||
In July 2019, the company acquired Therachon for up to $810{{nbsp}}million, expanding its rare disease portfolio through Therachon's recombinant human fibroblast growth factor receptor 3 compound, aimed at treating conditions such as [[achondroplasia]].<ref>{{Cite news |url=https://www.spglobal.com/marketintelligence/en/news-insights/trending/sWCcSrMgL8UmeCJXuuGp-w2 |title=Pfizer completes acquisition of Therachon to bolster rare disease drug portfolio |first=Ravikash |last=Bakolia |work=[[S&P Global]] |date=July 1, 2019}}</ref> Also in July, Pfizer acquired [[Array Biopharma]] for $10.6{{nbsp}}billion, boosting its oncology pipeline.<ref>{{Cite press release |url=https://www.businesswire.com/news/home/20190730005590/en/Pfizer-Completes-Acquisition-of-Array-Biopharma |title=Pfizer Completes Acquisition of Array Biopharma |publisher=Pfizer |via=[[Business Wire]] |date=July 30, 2019}}</ref> In August 2019, Pfizer merged its consumer health business with that of GlaxoSmithKline, into a [[joint venture]] owned 68% by GlaxoSmithKline and 32% by Pfizer, with plans to make it a [[public company]]. The transaction built on a 2018 transaction where GlaxoSmithKline acquired [[Novartis]]' stake in the GSK-Novartis consumer healthcare joint business.<ref>{{Cite news |url=https://www.bbc.co.uk/news/business-46616713 |title=GlaxoSmithKline and Pfizer merge healthcare arms |work=[[BBC News]] |date=December 19, 2018}}</ref> The transaction followed negotiations with other companies including [[Reckitt Benckiser]],<ref>{{Cite magazine |title=Reckitt Benckiser's still keen on a Pfizer OTC buy. But can it afford one? |url=https://www.fiercepharma.com/pharma/reckitt-benckiser-s-still-keen-a-pfizer-otc-buy-but-can-it-afford-one |magazine=Fierce Pharma |first=Carly |last=Helfand |date=October 16, 2017}}</ref> [[Sanofi]], [[Johnson & Johnson]],<ref>{{Cite magazine |title=Sanofi, J&J could join GlaxoSmithKline, Reckitt in $20B bidding war for Pfizer OTC: report |url=https://www.fiercepharma.com/pharma/sanofi-j-j-could-join-gsk-reckitt-20b-bidding-war-for-pfizer-otc-report |magazine=Fierce Pharma |first=Carly |last=Helfand |date=October 26, 2017}}</ref> and [[Procter & Gamble]].<ref>{{Cite magazine |title=GlaxoSmithKline eyes Pfizer's OTC unit. But will a buy imperil its dividend? |url=https://www.fiercepharma.com/pharma/glaxosmithkline-s-eyeing-pfizer-s-otc-unit-but-will-a-buy-imperil-its-dividend |magazine=Fierce Pharma |first=Carly |last=Helfand |date=October 25, 2017}}</ref> In September 2019, Pfizer initiated a study with the [[CDC Foundation]] to investigate the tracking of [[healthcare-associated infection]]s, scheduled to run through to June 2023.<ref name=":4" /> In December 2019, Pfizer awarded the CDC Foundation a further $1,948,482 to continue its [[cryptococcal disease]] screening and treatment research in nine African countries.<ref name=":4" /> | In July 2019, the company acquired Therachon for up to $810{{nbsp}}million, expanding its rare disease portfolio through Therachon's recombinant human fibroblast growth factor receptor 3 compound, aimed at treating conditions such as [[achondroplasia]].<ref>{{Cite news |url=https://www.spglobal.com/marketintelligence/en/news-insights/trending/sWCcSrMgL8UmeCJXuuGp-w2 |title=Pfizer completes acquisition of Therachon to bolster rare disease drug portfolio |first=Ravikash |last=Bakolia |work=[[S&P Global]] |date=July 1, 2019}}</ref> Also in July, Pfizer acquired [[Array Biopharma]] for $10.6{{nbsp}}billion, boosting its oncology pipeline.<ref>{{Cite press release |url=https://www.businesswire.com/news/home/20190730005590/en/Pfizer-Completes-Acquisition-of-Array-Biopharma |title=Pfizer Completes Acquisition of Array Biopharma |publisher=Pfizer |via=[[Business Wire]] |date=July 30, 2019}}</ref> In August 2019, Pfizer merged its consumer health business with that of GlaxoSmithKline, into a [[joint venture]] owned 68% by GlaxoSmithKline and 32% by Pfizer, with plans to make it a [[public company]]. The transaction built on a 2018 transaction where GlaxoSmithKline acquired [[Novartis]]' stake in the GSK-Novartis consumer healthcare joint business.<ref>{{Cite news |url=https://www.bbc.co.uk/news/business-46616713 |title=GlaxoSmithKline and Pfizer merge healthcare arms |work=[[BBC News]] |date=December 19, 2018}}</ref> The transaction followed negotiations with other companies including [[Reckitt Benckiser]],<ref>{{Cite magazine |title=Reckitt Benckiser's still keen on a Pfizer OTC buy. But can it afford one? |url=https://www.fiercepharma.com/pharma/reckitt-benckiser-s-still-keen-a-pfizer-otc-buy-but-can-it-afford-one |magazine=Fierce Pharma |first=Carly |last=Helfand |date=October 16, 2017}}</ref> [[Sanofi]], [[Johnson & Johnson]],<ref>{{Cite magazine |title=Sanofi, J&J could join GlaxoSmithKline, Reckitt in $20B bidding war for Pfizer OTC: report |url=https://www.fiercepharma.com/pharma/sanofi-j-j-could-join-gsk-reckitt-20b-bidding-war-for-pfizer-otc-report |magazine=Fierce Pharma |first=Carly |last=Helfand |date=October 26, 2017}}</ref> and [[Procter & Gamble]].<ref>{{Cite magazine |title=GlaxoSmithKline eyes Pfizer's OTC unit. But will a buy imperil its dividend? |url=https://www.fiercepharma.com/pharma/glaxosmithkline-s-eyeing-pfizer-s-otc-unit-but-will-a-buy-imperil-its-dividend |magazine=Fierce Pharma |first=Carly |last=Helfand |date=October 25, 2017}}</ref> In September 2019, Pfizer initiated a study with the [[CDC Foundation]] to investigate the tracking of [[healthcare-associated infection]]s, scheduled to run through to June 2023.<ref name=":4" /> In December 2019, Pfizer awarded the CDC Foundation a further $1,948,482 to continue its [[cryptococcal disease]] screening and treatment research in nine African countries.<ref name=":4" /> | ||
| Line 157: | Line 157: | ||
==== Development of oral antivirals ==== | ==== Development of oral antivirals ==== | ||
In November 2021, Pfizer launched a new COVID-19 oral antivirus treatment known as [[Nirmatrelvir/ritonavir|Paxlovid]]. In January 2022, the Pfizer CEO [[Albert Bourla]] confirmed that the trial results of a fourth dose were pending until March 2022. He said that the firm was setting up a collaboration to develop an anti-COVID pill treatment along with a French company, [[Novasep]]. He also said the COVID vaccine was "safe and efficient" for children.<ref>{{Cite web |url=https://www.israelnationalnews.com/news/320624 |title=Pfizer CEO: Current wave will be last with so many restrictions |access-date=17 January 2021 |website=[[Israel National News]]}}</ref><ref>{{Cite web |url=https://www.livemint.com/companies/news/pfizer-ceo-shares-some-good-news-on-covid-but-cautions-virus-could-circulate-for-years-11642405004050.html |title=Pfizer CEO shares some good news on covid but cautions virus could circulate for years |access-date=17 January 2021 |website=[[Mint (newspaper)|Mint]]}}</ref> In May 2022, reports emerged of patients experiencing "rebound" symptoms after completing a five-day course of Paxlovid.<ref>{{Cite news |last=Hopkins |first=Jared S. |date=2022-05-10 |title=Some Covid-19 Patients Relapse After Taking Paxlovid, Puzzling Doctors |work= | In November 2021, Pfizer launched a new COVID-19 oral antivirus treatment known as [[Nirmatrelvir/ritonavir|Paxlovid]]. In January 2022, the Pfizer CEO [[Albert Bourla]] confirmed that the trial results of a fourth dose were pending until March 2022. He said that the firm was setting up a collaboration to develop an anti-COVID pill treatment along with a French company, [[Novasep]]. He also said the COVID vaccine was "safe and efficient" for children.<ref>{{Cite web |url=https://www.israelnationalnews.com/news/320624 |title=Pfizer CEO: Current wave will be last with so many restrictions |access-date=17 January 2021 |website=[[Israel National News]]}}</ref><ref>{{Cite web |url=https://www.livemint.com/companies/news/pfizer-ceo-shares-some-good-news-on-covid-but-cautions-virus-could-circulate-for-years-11642405004050.html |title=Pfizer CEO shares some good news on covid but cautions virus could circulate for years |access-date=17 January 2021 |website=[[Mint (newspaper)|Mint]]}}</ref> In May 2022, reports emerged of patients experiencing "rebound" symptoms after completing a five-day course of Paxlovid.<ref>{{Cite news |last=Hopkins |first=Jared S. |date=2022-05-10 |title=Some Covid-19 Patients Relapse After Taking Paxlovid, Puzzling Doctors |work=The Wall Street Journal |url=https://www.wsj.com/articles/some-covid-19-patients-relapse-after-taking-paxlovid-puzzling-doctors-11652186194 |access-date=2022-05-16 |issn=0099-9660}}</ref> The FDA responded by announcing they had performed additional analyses of the drug's clinical trial data, and decided against changing its recommendations.<ref>{{Cite journal |last=Farley |first=John |date=2022-05-04 |title=FDA Updates on Paxlovid for Health Care Providers |url=https://www.fda.gov/drugs/news-events-human-drugs/fda-updates-paxlovid-health-care-providers |journal=[[Food and Drug Administration]] }}</ref> U.S. President [[Joe Biden]] and Dr. [[Anthony Fauci]] were both reported to experience this rebound syndrome in the months that followed, while continuing to recommend the drug for those who may benefit from it.<ref>{{Cite web |last=Samuels |first=Fionna M. D. |date=2022-08-08 |title=What Is Paxlovid Rebound, and How Common Is It? |url=https://www.scientificamerican.com/article/what-is-paxlovid-rebound-and-how-common-is-it/ |url-status=live |archive-url=https://archive.today/20220818063840/https://www.scientificamerican.com/article/what-is-paxlovid-rebound-and-how-common-is-it/ |archive-date=2022-08-18 |access-date=2022-08-22 |website=[[Scientific American]] }}</ref> | ||
===Late 2020–onwards: Corporate developments and acquisitions === | ===Late 2020–onwards: Corporate developments and acquisitions === | ||
In September 2020, the company acquired a 9.9% stake in CStone Pharmaceuticals for $200{{nbsp}}million (HK$1.55{{nbsp}}billion), helping to commercialise its anti-[[PD-L1]] monoclonal antibody, CS1001.<ref>{{Cite news |title=Pfizer to buy 9.9% of CStone for $200 million, eyes collaboration |url=https://www.reuters.com/article/us-cstone-pfizer/pfizer-to-buy-9-9-of-cstone-for-200-million-eyes-collaboration-idUKKBN26L01D |work=[[Reuters]] |date=September 29, 2020}}</ref> In October 2020, the company acquired Arixa Pharmaceuticals.<ref>{{Cite magazine |url=https://www.fiercebiotech.com/biotech/pfizer-snaps-up-antibiotics-maker-arixa-and-its-oral-avycaz-follow-up |title=Biotech Pfizer snaps up antibiotics maker Arixa and its oral Avycaz follow-up |first=Amirah |last=Al Idrus |magazine=Fierce Pharma |date=October 22, 2020}}</ref> In November 2020, using a [[Reverse Morris Trust]] structure, Pfizer merged its off-patent branded and [[generic drug]] business, known as Upjohn, with [[Mylan]] to form [[Viatris]], owned 57% by Pfizer shareholders.<ref>{{Cite news |url=https://www.nasdaq.com/articles/pfizer-completes-combination-of-upjohn-and-mylan-viatris-to-begin-trading-on-nov.-17-2020 |title=Pfizer Completes Combination Of Upjohn And Mylan; Viatris To Begin Trading On Nov. 17 |work=[[Nasdaq]] |date=November 16, 2020}}</ref><ref>{{Cite news |url=https://www.post-gazette.com/business/healthcare-business/2020/11/16/Mylan-merger-Upjohn-Viatris-bresch-coury-Pfizer-cost-cuts-generic-drugs/stories/202011160111 |title=Mylan completes merger with Upjohn to form Viatris |first=Patricia |last=Sabatini |work=[[Pittsburgh Post-Gazette]] |date=November 16, 2020}}</ref> | In September 2020, the company acquired a 9.9% stake in CStone Pharmaceuticals for $200{{nbsp}}million (HK$1.55{{nbsp}}billion), helping to commercialise its anti-[[PD-L1]] monoclonal antibody, CS1001.<ref>{{Cite news |title=Pfizer to buy 9.9% of CStone for $200 million, eyes collaboration |url=https://www.reuters.com/article/us-cstone-pfizer/pfizer-to-buy-9-9-of-cstone-for-200-million-eyes-collaboration-idUKKBN26L01D |work=[[Reuters]] |date=September 29, 2020}}</ref> In October 2020, the company acquired Arixa Pharmaceuticals.<ref>{{Cite magazine |url=https://www.fiercebiotech.com/biotech/pfizer-snaps-up-antibiotics-maker-arixa-and-its-oral-avycaz-follow-up |title=Biotech Pfizer snaps up antibiotics maker Arixa and its oral Avycaz follow-up |first=Amirah |last=Al Idrus |magazine=Fierce Pharma |date=October 22, 2020}}</ref> In November 2020, using a [[Reverse Morris Trust]] structure, Pfizer merged its off-patent branded and [[generic drug]] business, known as Upjohn, with [[Mylan]] to form [[Viatris]], owned 57% by Pfizer shareholders.<ref>{{Cite news |url=https://www.nasdaq.com/articles/pfizer-completes-combination-of-upjohn-and-mylan-viatris-to-begin-trading-on-nov.-17-2020 |title=Pfizer Completes Combination Of Upjohn And Mylan; Viatris To Begin Trading On Nov. 17 |work=[[Nasdaq]] |date=November 16, 2020}}</ref><ref>{{Cite news |url=https://www.post-gazette.com/business/healthcare-business/2020/11/16/Mylan-merger-Upjohn-Viatris-bresch-coury-Pfizer-cost-cuts-generic-drugs/stories/202011160111 |title=Mylan completes merger with Upjohn to form Viatris |first=Patricia |last=Sabatini |work=[[Pittsburgh Post-Gazette]] |date=November 16, 2020}}</ref> | ||
On January 5, 2021, Pfizer introduced a new [[logo]].<ref>{{Cite news |last=Bruell |first=Alexandra |title=Pfizer Introduces New Logo Playing Up Role in Drug Creation |url=https://www.wsj.com/articles/pfizer-introduces-new-logo-playing-up-role-in-drug-creation-11609844400 |work= | On January 5, 2021, Pfizer introduced a new [[logo]].<ref>{{Cite news |last=Bruell |first=Alexandra |title=Pfizer Introduces New Logo Playing Up Role in Drug Creation |url=https://www.wsj.com/articles/pfizer-introduces-new-logo-playing-up-role-in-drug-creation-11609844400 |work=The Wall Street Journal |date=January 5, 2021 |issn=0099-9660 |url-access=subscription}}</ref> In April 2021, Pfizer acquired Amplyx Pharmaceuticals and its anti-fungal compound [[fosmanogepix]] (APX001).<ref>{{cite magazine |url=https://www.fiercebiotech.com/biotech/pfizer-buys-amplyx-to-grow-infectious-disease-pipeline |title=Pfizer buys Amplyx to grow infectious disease pipeline |first=Nick Paul |last=Taylor |magazine=Fierce Pharma |date=April 28, 2021}}</ref><ref>{{Cite news |url=https://www.sandiegouniontribune.com/business/biotech/story/2021-04-28/pfizer-acquires-fungus-fighting-san-diego-biotech-amplyx |title=Pfizer acquires fungus-fighting San Diego biotech |first=Jonathan |last=Wosen |work=[[The San Diego Union-Tribune]] |date=April 28, 2021}}</ref> In August, the company announced it would acquire Trillium Therapeutics Inc and its immuno-oncology portfolio for $2.3 billion.<ref>{{Cite news |url=https://www.reuters.com/business/pfizer-buy-trillium-therapeutics-226-bln-deal-2021-08-23/ |title=Pfizer to buy cancer drug developer Trillium in $2.3 BLN deal |newspaper=Reuters |date=August 23, 2021}}</ref><ref>{{Cite web |url=https://www.biospace.com/article/releases/pfizer-to-acquire-trillium-therapeutics-inc-/?s=79 |title=Pfizer to Acquire Trillium Therapeutics Inc}}</ref> | ||
In March 2022, the company acquired [[Arena Pharmaceuticals]] for $6.7 billion in cash.<ref>{{Cite press release | url=https://www.businesswire.com/news/home/20220310005794/en/Pfizer-Completes-Acquisition-of-Arena-Pharmaceuticals | title=Pfizer Completes Acquisition of Arena Pharmaceuticals | publisher=[[Business Wire]] | date=March 11, 2022}}</ref><ref>{{cite web |title=Pfizer bets on Arena's promising bowel disease treatment in $6.7 bln deal |url=https://www.reuters.com/markets/deals/pfizer-acquire-arena-pharmaceuticals-67-bln-deal-2021-12-13 |work=[[Reuters]] |date=December 13, 2021 |access-date=December 13, 2021}}</ref><ref>{{cite web |title=Pfizer to Acquire Arena Pharmaceuticals in $6.7 Billion Deal |url=https://www.wsj.com/articles/pfizer-to-acquire-arena-pharmaceuticals-in-6-7-billion-deal-11639414813 |work= | In March 2022, the company acquired [[Arena Pharmaceuticals]] for $6.7 billion in cash.<ref>{{Cite press release | url=https://www.businesswire.com/news/home/20220310005794/en/Pfizer-Completes-Acquisition-of-Arena-Pharmaceuticals | title=Pfizer Completes Acquisition of Arena Pharmaceuticals | publisher=[[Business Wire]] | date=March 11, 2022}}</ref><ref>{{cite web |title=Pfizer bets on Arena's promising bowel disease treatment in $6.7 bln deal |url=https://www.reuters.com/markets/deals/pfizer-acquire-arena-pharmaceuticals-67-bln-deal-2021-12-13 |work=[[Reuters]] |date=December 13, 2021 |access-date=December 13, 2021}}</ref><ref>{{cite web |title=Pfizer to Acquire Arena Pharmaceuticals in $6.7 Billion Deal |url=https://www.wsj.com/articles/pfizer-to-acquire-arena-pharmaceuticals-in-6-7-billion-deal-11639414813 |work=The Wall Street Journal |last=Walker |first=Joseph |date=December 13, 2021 |access-date=December 13, 2021}}</ref> In June 2022, the company acquired ReViral Ltd, for up to $525 million, gaining access to experimental drugs used to combat [[respiratory syncytial virus]] infections.<ref>{{Cite news | url=https://www.reuters.com/business/healthcare-pharmaceuticals/pfizer-buy-rsv-drug-developer-reviral-up-525-mln-2022-04-07/ | title=Pfizer boosts respiratory drug portfolio with ReViral purchase | newspaper=Reuters | date=April 7, 2022 | last1=Satija | first1=Bhanvi }}</ref><ref>{{Cite web |date=2022-06-10 |title=Pfizer acquires biopharma firm ReViral for up to $525m |url=https://www.pharmaceutical-technology.com/news/pfizer-acquires-biopharma-reviral/ |access-date=2022-06-10 |website=Pharmaceutical Technology }}</ref> In October 2022, the company acquired Biohaven Pharma and its [[calcitonin gene-related peptide]] programs for $11.6 billion.<ref>{{cite web | url=https://www.biospace.com/article/releases/pfizer-completes-acquisition-of-biohaven-pharmaceuticals/?s=110 | title=Pfizer Completes Acquisition of Biohaven Pharmaceuticals | date=October 3, 2022 }}</ref><ref>{{cite press release | url=https://www.businesswire.com/news/home/20220510005676/en/ | title=Pfizer to Acquire Biohaven Pharmaceuticals | date=May 10, 2022}}</ref><ref>{{cite web | url=https://www.biospace.com/article/pfizer-drops-a-cool-11-6-billion-on-migraine-leader-biohaven-/?s=79 | title=Pfizer Drops a Cool $11.6B on Migraine Leader Biohaven }}</ref> It also acquired Global Blood Therapeutics for $5.4 billion, boosting Pfizer's rare disease business.<ref>{{Cite press release | url=https://www.businesswire.com/news/home/20221004006158/en/Pfizer-Completes-Acquisition-of-Global-Blood-Therapeutics%C2%A0 | title=Pfizer Completes Acquisition of Global Blood Therapeutics | publisher=[[Business Wire]] | date=October 5, 2022}}</ref><ref>{{Cite news |last=Rockoff |first=Jonathan D. |date=2022-08-08 |title=Pfizer Agrees to $5.4 Billion Deal for Global Blood Therapeutics |work=The Wall Street Journal |url=https://www.wsj.com/articles/pfizer-reaches-5-4-billion-deal-for-global-blood-therapeutics-11659954601 |access-date=2022-08-08 |issn=0099-9660}}</ref><ref>{{Cite news |date=2022-08-08 |title=Flush with cash, Pfizer buys Global Blood Therapeutics in $5.4 billion deal |work=Reuters |url=https://www.reuters.com/business/healthcare-pharmaceuticals/pfizer-buy-global-blood-therapeutics-54-bln-deal-2022-08-08/ |access-date=2022-08-08}}</ref> | ||
In April 2023, Pfizer moved its world headquarters from [[42nd Street (Manhattan)|42nd Street]] in [[Midtown Manhattan]] to the Spiral at [[Hudson Yards (development)|Hudson Yards]].<ref>{{cite news |url=https://www.crainsnewyork.com/health-care/pfizer-opens-global-headquarters-hudson-yards-empty-offices-reach-pandemic-levels |last1=D'Ambrosio |first1=Amanda |title=Pfizer opens global headquarters in Hudson Yards as empty offices reach pandemic levels |work=[[Crain Communications]] |date=April 3, 2023}}</ref><ref>{{cite magazine |url=https://www.fiercepharma.com/pharma/pfizer-moves-west-side-settling-down-swanky-new-digs-hudson-yards-spiral-skyscraper |last1=Liu |first1=Angus |last2=Kansteiner |first2=Fraiser |title=Pfizer moves on up to the West Side, establishing new nerve center at Hudson Yards' Spiral skyscraper |magazine=Fierce Pharma |date=April 4, 2023}}</ref> | In April 2023, Pfizer moved its world headquarters from [[42nd Street (Manhattan)|42nd Street]] in [[Midtown Manhattan]] to the Spiral at [[Hudson Yards (development)|Hudson Yards]].<ref>{{cite news |url=https://www.crainsnewyork.com/health-care/pfizer-opens-global-headquarters-hudson-yards-empty-offices-reach-pandemic-levels |last1=D'Ambrosio |first1=Amanda |title=Pfizer opens global headquarters in Hudson Yards as empty offices reach pandemic levels |work=[[Crain Communications]] |date=April 3, 2023}}</ref><ref>{{cite magazine |url=https://www.fiercepharma.com/pharma/pfizer-moves-west-side-settling-down-swanky-new-digs-hudson-yards-spiral-skyscraper |last1=Liu |first1=Angus |last2=Kansteiner |first2=Fraiser |title=Pfizer moves on up to the West Side, establishing new nerve center at Hudson Yards' Spiral skyscraper |magazine=Fierce Pharma |date=April 4, 2023}}</ref> | ||