Pfizer: Difference between revisions

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In 1986, Pfizer acquired the worldwide rights to Zithromax ([[azithromycin]]), a macrolide antibiotic that is recommended by the [[Infectious Disease Society of America]] as a first line treatment for certain cases of community-acquired pneumonia, from [[Pliva]].<ref name="best">{{cite web |url=https://www.wipo.int/ipadvantage/en/details.jsp?id=906 |title=Azithromycin: A world best-selling Antibiotic |publisher=[[World Intellectual Property Organization]]}}</ref><ref>{{Cite journal |vauthors=Mandell LA, Wunderink RG, Anzueto A, etal |date=March 2007 |title=Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults |url=https://www.thoracic.org/statements/resources/mtpi/idsaats-cap.pdf |journal=Clinical Infectious Diseases |volume=44 |issue=Suppl 2 |pages=S27–72 |doi=10.1086/511159 |pmc=7107997 |pmid=17278083}}</ref>
In 1986, Pfizer acquired the worldwide rights to Zithromax ([[azithromycin]]), a macrolide antibiotic that is recommended by the [[Infectious Disease Society of America]] as a first line treatment for certain cases of community-acquired pneumonia, from [[Pliva]].<ref name="best">{{cite web |url=https://www.wipo.int/ipadvantage/en/details.jsp?id=906 |title=Azithromycin: A world best-selling Antibiotic |publisher=[[World Intellectual Property Organization]]}}</ref><ref>{{Cite journal |vauthors=Mandell LA, Wunderink RG, Anzueto A, etal |date=March 2007 |title=Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults |url=https://www.thoracic.org/statements/resources/mtpi/idsaats-cap.pdf |journal=Clinical Infectious Diseases |volume=44 |issue=Suppl 2 |pages=S27–72 |doi=10.1086/511159 |pmc=7107997 |pmid=17278083}}</ref>


In 1989, Pfizer scientists Peter Dunn and Albert Wood created Viagra ([[sildenafil]]) for treating [[high blood pressure]] and [[angina]], a chest pain associated with [[coronary artery disease]]. In 1991, it was patented in the United Kingdom as a heart medication. Early trials for the medication showed that it did not work for the treatment of heart disease, but volunteers in the clinical trials had increased [[erection]]s several days after taking the drug. It was patented in the United States in 1996 and received approval by the [[Food and Drug Administration]] in March 1998. In December 1998, Pfizer hired [[Bob Dole]] as a spokesperson for the drug.<ref>{{Cite news |url=https://www.cnn.com/2013/03/27/health/viagra-anniversary-timeline/index.html |title=Viagra: The little blue pill that could |first=Jacque |last=Wilson |work=[[CNN]] |date=March 27, 2013}}</ref> The patents for Viagra expired in 2020.<ref>{{Cite news |url=https://www.theguardian.com/science/2019/jun/09/race-to-replace-viagra-patents-erectile-dysfunction-drug-medical-research-cialis-eroxon |title=The race to replace Viagra |first=David |last=Cox |work=[[The Guardian]] |date=June 9, 2019}}</ref>
In 1989, Pfizer scientists Peter Dunn and Albert Wood created Viagra ([[sildenafil]]) for treating [[high blood pressure]] and [[angina]], a chest pain associated with [[coronary artery disease]]. In 1991, it was patented in the United Kingdom as a heart medication. Early trials for the medication showed that it did not work for the treatment of heart disease, but volunteers in the clinical trials had increased [[erection]]s several days after taking the drug. It was patented in the United States in 1996 and received approval by the [[Food and Drug Administration]] in March 1998. In December 1998, Pfizer hired [[Bob Dole]] as a spokesperson for the drug.<ref>{{Cite news |url=https://www.cnn.com/2013/03/27/health/viagra-anniversary-timeline/index.html |title=Viagra: The little blue pill that could |first=Jacque |last=Wilson |work=CNN |date=March 27, 2013}}</ref> The patents for Viagra expired in 2020.<ref>{{Cite news |url=https://www.theguardian.com/science/2019/jun/09/race-to-replace-viagra-patents-erectile-dysfunction-drug-medical-research-cialis-eroxon |title=The race to replace Viagra |first=David |last=Cox |work=[[The Guardian]] |date=June 9, 2019}}</ref>


In 1991, [[William C. Steere, Jr.]] became [[chief executive officers]] of the company, succeeding [[Edmund T. Pratt Jr.]]<ref>{{Cite news |url=https://www.latimes.com/archives/la-xpm-1991-03-29-fi-903-story.html |title=Pfizer Inc., New York, has elected its... |work=[[Los Angeles Times]] |date=March 29, 1991}}</ref>
In 1991, [[William C. Steere, Jr.]] became [[chief executive officers]] of the company, succeeding [[Edmund T. Pratt Jr.]]<ref>{{Cite news |url=https://www.latimes.com/archives/la-xpm-1991-03-29-fi-903-story.html |title=Pfizer Inc., New York, has elected its... |work=[[Los Angeles Times]] |date=March 29, 1991}}</ref>
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In 2004, the company received approval for Lyrica ([[pregabalin]]), an [[anticonvulsant]] and [[anxiolytic]] medication used to treat [[epilepsy]], [[neuropathic pain]], [[fibromyalgia]], [[restless leg syndrome]], and [[generalized anxiety disorder]].<ref>{{Cite web |title=Pregabalin |url=https://www.drugs.com/monograph/pregabalin.html |publisher=[[American Society of Health-System Pharmacists]]}}</ref><ref>{{cite journal |last1=Frampton |first1=James E. |title=Pregabalin: A Review of its Use in Adults with Generalized Anxiety Disorder |journal=CNS Drugs |date=September 2014 |volume=28 |issue=9 |pages=835–854 |doi=10.1007/s40263-014-0192-0 |pmid=25149863 |s2cid=5349255}}</ref><ref>{{cite journal |last1=Iftikhar |first1=I. H. |last2=Alghothani |first2=L. |last3=Trotti |first3=L. M. |title=Gabapentin enacarbil, pregabalin and rotigotine are equally effective in restless legs syndrome: a comparative meta-analysis |journal=[[European Journal of Neurology]] |date=December 2017 |volume=24 |issue=12 |pages=1446–1456 |doi=10.1111/ene.13449 |pmid=28888061 |s2cid=22262972}}</ref> The United States patent on Lyrica was challenged by generic manufacturers and was upheld in 2014, extending the expiration date to 2018.<ref>{{Cite news |last=Decker |first=Susan |date=February 6, 2014 |title=Pfizer Wins Ruling to Block Generic Lyrica Until 2018 |work=[[Bloomberg News]] |url=https://www.bloomberg.com/news/2014-02-06/pfizer-wins-ruling-to-block-generic-lyrica-until-2018.html |url-access=subscription}}</ref>
In 2004, the company received approval for Lyrica ([[pregabalin]]), an [[anticonvulsant]] and [[anxiolytic]] medication used to treat [[epilepsy]], [[neuropathic pain]], [[fibromyalgia]], [[restless leg syndrome]], and [[generalized anxiety disorder]].<ref>{{Cite web |title=Pregabalin |url=https://www.drugs.com/monograph/pregabalin.html |publisher=[[American Society of Health-System Pharmacists]]}}</ref><ref>{{cite journal |last1=Frampton |first1=James E. |title=Pregabalin: A Review of its Use in Adults with Generalized Anxiety Disorder |journal=CNS Drugs |date=September 2014 |volume=28 |issue=9 |pages=835–854 |doi=10.1007/s40263-014-0192-0 |pmid=25149863 |s2cid=5349255}}</ref><ref>{{cite journal |last1=Iftikhar |first1=I. H. |last2=Alghothani |first2=L. |last3=Trotti |first3=L. M. |title=Gabapentin enacarbil, pregabalin and rotigotine are equally effective in restless legs syndrome: a comparative meta-analysis |journal=[[European Journal of Neurology]] |date=December 2017 |volume=24 |issue=12 |pages=1446–1456 |doi=10.1111/ene.13449 |pmid=28888061 |s2cid=22262972}}</ref> The United States patent on Lyrica was challenged by generic manufacturers and was upheld in 2014, extending the expiration date to 2018.<ref>{{Cite news |last=Decker |first=Susan |date=February 6, 2014 |title=Pfizer Wins Ruling to Block Generic Lyrica Until 2018 |work=[[Bloomberg News]] |url=https://www.bloomberg.com/news/2014-02-06/pfizer-wins-ruling-to-block-generic-lyrica-until-2018.html |url-access=subscription}}</ref>


In July 2006, [[Jeff Kindler]] was named [[chief executive officer]] of the company, replacing [[Henry McKinnell]].<ref name="longshot" /><ref>{{Cite news |date=July 28, 2006 |title=Pfizer names new CEO |work=[[CNN]] |url=https://money.cnn.com/2006/07/28/news/companies/pfizer_ceo/index.htm}}</ref>
In July 2006, [[Jeff Kindler]] was named [[chief executive officer]] of the company, replacing [[Henry McKinnell]].<ref name="longshot" /><ref>{{Cite news |date=July 28, 2006 |title=Pfizer names new CEO |work=CNN |url=https://money.cnn.com/2006/07/28/news/companies/pfizer_ceo/index.htm}}</ref>


On December 3, 2006, Pfizer ceased development of [[torcetrapib]], a drug that increases production of [[high density lipoprotein|HDL]], which reduces [[low density lipoprotein|LDL]] thought to be correlated to heart disease. During a [[Phase III clinical trial]] involving 15,000 patients, more deaths than expected occurred in the group that took the medicine, and the [[mortality rate]] of patients taking the combination of torcetrapib and Lipitor (82 deaths during the study) was 60% higher than those taking Lipitor alone (52 deaths during the study). Lipitor alone was not implicated in the results, but Pfizer lost nearly $1{{nbsp}}billion developing the failed drug and its stock price dropped 11% on the day of the announcement.<ref>{{Cite news |last1=Berenson |first1=Alex |last2=Pollack |first2=Andrew |date=December 5, 2006 |title=Pfizer Shares Plummet on Loss of a Promising Heart Drug |work=[[The New York Times]] |url=https://www.nytimes.com/2006/12/05/health/05pfizer.html |url-access=limited}}</ref><ref>{{Cite news |last=Berenson |first=Alex |date=December 3, 2006 |title=Pfizer Ends Studies on Drug for Heart Disease |work=[[The New York Times]] |url=https://www.nytimes.com/2006/12/03/health/03pfizer.html |url-access=limited |authorlink=Alex Berenson}}</ref><ref>{{Cite news |last=Agovino |first=Theresa |date=December 3, 2006 |title=Pfizer ends cholesterol drug development |publisher=[[The Seattle Times]] |agency=[[Associated Press]] |url=https://www.seattletimes.com/nation-world/cholesterol-drug-trials-are-halted/}}</ref><ref>{{cite journal |last1=Tanne |first1=Janice Hopkins |title=Pfizer stops clinical trials of heart drug |journal=BMJ |date=16 December 2006 |volume=333 |issue=7581 |pages=1237.2–1237 |doi=10.1136/bmj.39059.438044.DB |pmid=17170401 |pmc=1702474}}</ref>
On December 3, 2006, Pfizer ceased development of [[torcetrapib]], a drug that increases production of [[high density lipoprotein|HDL]], which reduces [[low density lipoprotein|LDL]] thought to be correlated to heart disease. During a [[Phase III clinical trial]] involving 15,000 patients, more deaths than expected occurred in the group that took the medicine, and the [[mortality rate]] of patients taking the combination of torcetrapib and Lipitor (82 deaths during the study) was 60% higher than those taking Lipitor alone (52 deaths during the study). Lipitor alone was not implicated in the results, but Pfizer lost nearly $1{{nbsp}}billion developing the failed drug and its stock price dropped 11% on the day of the announcement.<ref>{{Cite news |last1=Berenson |first1=Alex |last2=Pollack |first2=Andrew |date=December 5, 2006 |title=Pfizer Shares Plummet on Loss of a Promising Heart Drug |work=[[The New York Times]] |url=https://www.nytimes.com/2006/12/05/health/05pfizer.html |url-access=limited}}</ref><ref>{{Cite news |last=Berenson |first=Alex |date=December 3, 2006 |title=Pfizer Ends Studies on Drug for Heart Disease |work=[[The New York Times]] |url=https://www.nytimes.com/2006/12/03/health/03pfizer.html |url-access=limited |authorlink=Alex Berenson}}</ref><ref>{{Cite news |last=Agovino |first=Theresa |date=December 3, 2006 |title=Pfizer ends cholesterol drug development |publisher=[[The Seattle Times]] |agency=[[Associated Press]] |url=https://www.seattletimes.com/nation-world/cholesterol-drug-trials-are-halted/}}</ref><ref>{{cite journal |last1=Tanne |first1=Janice Hopkins |title=Pfizer stops clinical trials of heart drug |journal=BMJ |date=16 December 2006 |volume=333 |issue=7581 |pages=1237.2–1237 |doi=10.1136/bmj.39059.438044.DB |pmid=17170401 |pmc=1702474}}</ref>
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Between 2007 and 2010, Pfizer spent $3.3{{nbsp}}million on investigations and legal fees and recovered about $5.1{{nbsp}}million, and had another $5{{nbsp}}million of pending recoveries from civil lawsuits against makers of [[counterfeit]] prescription drugs. Pfizer has hired customs and narcotics experts worldwide to track down fakes and assemble evidence that can be used to pursue civil suits for [[trademark infringement]].<ref>{{Cite news |last=Bennett |first=Simeon |date=July 8, 2010 |title=Pfizer: Civil Suits for Drug Counterfeiters |work=[[Bloomberg Businessweek]] |url=https://www.bloomberg.com/news/articles/2010-07-08/pfizer-civil-suits-for-drug-counterfeiters |url-access=limited}}</ref>
Between 2007 and 2010, Pfizer spent $3.3{{nbsp}}million on investigations and legal fees and recovered about $5.1{{nbsp}}million, and had another $5{{nbsp}}million of pending recoveries from civil lawsuits against makers of [[counterfeit]] prescription drugs. Pfizer has hired customs and narcotics experts worldwide to track down fakes and assemble evidence that can be used to pursue civil suits for [[trademark infringement]].<ref>{{Cite news |last=Bennett |first=Simeon |date=July 8, 2010 |title=Pfizer: Civil Suits for Drug Counterfeiters |work=[[Bloomberg Businessweek]] |url=https://www.bloomberg.com/news/articles/2010-07-08/pfizer-civil-suits-for-drug-counterfeiters |url-access=limited}}</ref>


In July 2008, Pfizer announced 275 job cuts at its manufacturing facility in [[Portage, Michigan]]. Portage was previously the world headquarters of [[Upjohn Company]], which had been acquired as part of Pharmacia.<ref>{{Cite news |last=Jones |first=Al |date=July 15, 2008 |title=Pfizer job cuts don't equal a reduction in work load, says company spokesman |work=[[Booth Newspapers]] |url=https://www.mlive.com/kzgazette/2008/07/pfizer_job_cuts_dont_equal_a_r.html}}</ref><ref name=":0">{{Cite news |date=April 16, 2003 |title=It's official: Pfizer buys Pharmacia |work=[[CNN]] |url=https://money.cnn.com/2003/04/16/news/companies/pfizer_pharma/}}</ref>
In July 2008, Pfizer announced 275 job cuts at its manufacturing facility in [[Portage, Michigan]]. Portage was previously the world headquarters of [[Upjohn Company]], which had been acquired as part of Pharmacia.<ref>{{Cite news |last=Jones |first=Al |date=July 15, 2008 |title=Pfizer job cuts don't equal a reduction in work load, says company spokesman |work=[[Booth Newspapers]] |url=https://www.mlive.com/kzgazette/2008/07/pfizer_job_cuts_dont_equal_a_r.html}}</ref><ref name=":0">{{Cite news |date=April 16, 2003 |title=It's official: Pfizer buys Pharmacia |work=CNN |url=https://money.cnn.com/2003/04/16/news/companies/pfizer_pharma/}}</ref>


==== Acquisitions and mergers ====
==== Acquisitions and mergers ====
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====2014 Illegal marketing settlement====
====2014 Illegal marketing settlement====
In June 2010, health insurance network [[Blue Cross Blue Shield]] (BCBS) filed a lawsuit against Pfizer for allegedly illegally marketing drugs Bextra, Geodon and Lyrica. BCBS alleged that Pfizer used kickbacks and wrongly persuaded doctors to prescribe the drugs.<ref>{{Cite news |title=Blue Cross Names and Shames Pfizer Execs Linked to Massages-for-Prescriptions Push |url=https://www.cbsnews.com/news/blue-cross-names-and-shames-pfizer-execs-linked-to-massages-for-prescriptions-push/ |first=Jim |last=Edwards |work=[[CBS News]] |date=June 10, 2010}}</ref><ref>{{Cite news |url=https://www.bizjournals.com/austin/stories/2010/06/07/daily52.html |title=Blue Cross Blue Shield of Texas sues Pfizer |last=Bounds |first=Jeff |work=[[American City Business Journals]] |date=June 10, 2010}}</ref> According to the lawsuit, Pfizer handed out 'misleading' materials on [[off-label use]]s, sent over 5,000 doctors on trips to the [[Caribbean]] or around the United States, and paid them $2,000 honoraria in return for listening to lectures about Bextra.<ref>{{Cite magazine |url=https://www.fiercepharma.com/pharma/bcbs-names-pfizer-managers-kickback-suit |title=BCBS names Pfizer managers in kickback suit |magazine=Fierce Pharma |first=Tracy |last=Staton |date=June 11, 2010}}</ref><ref>{{Cite news |url=https://www.dallasnews.com/business/2010/06/11/blue-cross-blue-shield-of-texas-sues-pfizer-over-drug-marketing/ |title=Blue Cross Blue Shield of Texas sues Pfizer over drug marketing |work=[[The Dallas Morning News]] |date=June 11, 2010 |url-access=subscription}}</ref> Despite Pfizer's claims that "the company's intent was pure" in fostering a legal exchange of information among doctors, an internal marketing plan revealed that Pfizer intended to train physicians "to serve as public relations spokespeople."<ref name=toobig/> The case was settled in 2014 for $325{{nbsp}}million.<ref>{{Cite news |title=Pfizer Agrees to $325 Million Neurontin Marketing Accord |url=https://www.bloomberg.com/news/2014-06-02/pfizer-agrees-to-325-million-settlment-over-neurontin.html |first=Christie |last=Smythe |work=[[Bloomberg News]] |date=June 2, 2014 |url-access=subscription}}</ref> Fearing that Pfizer is "[[too big to fail]]" and that prosecuting the company would result in disruptions to [[Medicare (United States)|Medicare]] and [[Medicaid]], federal prosecutors instead charged a subsidiary of a subsidiary of a subsidiary of Pfizer, which is "nothing more than a shell company whose only function is to plead guilty."<ref name=toobig>{{cite news |url=https://edition.cnn.com/2010/HEALTH/04/02/pfizer.bextra/index.html |title=Feds found Pfizer too big to nail |last1=Griffin |first1=Drew |last2=Segal |first2=Andy |work=[[CNN]] |date=April 2, 2010}}</ref>
In June 2010, health insurance network [[Blue Cross Blue Shield]] (BCBS) filed a lawsuit against Pfizer for allegedly illegally marketing drugs Bextra, Geodon and Lyrica. BCBS alleged that Pfizer used kickbacks and wrongly persuaded doctors to prescribe the drugs.<ref>{{Cite news |title=Blue Cross Names and Shames Pfizer Execs Linked to Massages-for-Prescriptions Push |url=https://www.cbsnews.com/news/blue-cross-names-and-shames-pfizer-execs-linked-to-massages-for-prescriptions-push/ |first=Jim |last=Edwards |work=[[CBS News]] |date=June 10, 2010}}</ref><ref>{{Cite news |url=https://www.bizjournals.com/austin/stories/2010/06/07/daily52.html |title=Blue Cross Blue Shield of Texas sues Pfizer |last=Bounds |first=Jeff |work=[[American City Business Journals]] |date=June 10, 2010}}</ref> According to the lawsuit, Pfizer handed out 'misleading' materials on [[off-label use]]s, sent over 5,000 doctors on trips to the [[Caribbean]] or around the United States, and paid them $2,000 honoraria in return for listening to lectures about Bextra.<ref>{{Cite magazine |url=https://www.fiercepharma.com/pharma/bcbs-names-pfizer-managers-kickback-suit |title=BCBS names Pfizer managers in kickback suit |magazine=Fierce Pharma |first=Tracy |last=Staton |date=June 11, 2010}}</ref><ref>{{Cite news |url=https://www.dallasnews.com/business/2010/06/11/blue-cross-blue-shield-of-texas-sues-pfizer-over-drug-marketing/ |title=Blue Cross Blue Shield of Texas sues Pfizer over drug marketing |work=[[The Dallas Morning News]] |date=June 11, 2010 |url-access=subscription}}</ref> Despite Pfizer's claims that "the company's intent was pure" in fostering a legal exchange of information among doctors, an internal marketing plan revealed that Pfizer intended to train physicians "to serve as public relations spokespeople."<ref name=toobig/> The case was settled in 2014 for $325{{nbsp}}million.<ref>{{Cite news |title=Pfizer Agrees to $325 Million Neurontin Marketing Accord |url=https://www.bloomberg.com/news/2014-06-02/pfizer-agrees-to-325-million-settlment-over-neurontin.html |first=Christie |last=Smythe |work=[[Bloomberg News]] |date=June 2, 2014 |url-access=subscription}}</ref> Fearing that Pfizer is "[[too big to fail]]" and that prosecuting the company would result in disruptions to [[Medicare (United States)|Medicare]] and [[Medicaid]], federal prosecutors instead charged a subsidiary of a subsidiary of a subsidiary of Pfizer, which is "nothing more than a shell company whose only function is to plead guilty."<ref name=toobig>{{cite news |url=https://edition.cnn.com/2010/HEALTH/04/02/pfizer.bextra/index.html |title=Feds found Pfizer too big to nail |last1=Griffin |first1=Drew |last2=Segal |first2=Andy |work=CNN |date=April 2, 2010}}</ref>


===2013 Quigley Company asbestos settlement===
===2013 Quigley Company asbestos settlement===