Center for Cancer Research
Stored: Center for Cancer Research
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Center for Cancer Research (CCR) is the intramural research arm of the National Cancer Institute (NCI), established to conduct cutting-edge cancer research and clinical trials at NCI facilities in Bethesda and Frederick, Maryland, under the authority of the National Cancer Act of 1937. With over 250 principal investigators and a workforce of approximately 4,000, CCR pioneers discoveries in cancer biology, immunotherapy, and precision medicine, treating patients at the NIH Clinical Center while advancing therapies like CAR T-cell treatments through its robust research infrastructure.
Mission
The Center for Cancer Research aims to unravel the mechanisms of cancer through basic and translational research, translating findings into novel diagnostics and treatments via clinical trials at the NIH Clinical Center. It fosters collaboration across disciplines to address unmet needs in cancer care, emphasizing innovation and patient-focused outcomes.[1]
Parent organization
The Center for Cancer Research operates under the National Cancer Institute, the federal leader in cancer research, within the National Institutes of Health, part of the Department of Health and Human Services.[2]
Legislation
The CCR was not created by specific legislation but evolved as NCI’s intramural research division following the National Cancer Act of 1937, with its scope expanded by the National Cancer Act of 1971 to include a comprehensive research program.[3]
Partners
The CCR collaborates with:
- NIH Clinical Center for patient trials
- Frederick National Laboratory for Cancer Research for advanced studies
- Academic and industry partners for translational research[4]
Number of employees
The CCR employs approximately 4,000 staff, including over 250 principal investigators, postdoctoral fellows, clinicians, and support personnel across its Bethesda and Frederick sites.[5]
Organization structure
The CCR is organized into branches and programs:
- Office of the Director oversees research strategy and operations.
- Basic Research Branches focus on cancer biology and genetics.
- Clinical Research Programs conduct trials and patient care.
Leader
The Center for Cancer Research is headed by a Director, currently Tom Misteli, Ph.D., appointed in 2012.[6]
Divisions
The divisions include:
- Basic Research for studies in genomics and molecular biology.[7]
- Translational Research for developing therapies from lab findings.
- Clinical Research for trials at the NIH Clinical Center.[8]
List of programs
The CCR oversees:
- NCI Experimental Therapeutics (NExT) Program - https://ccr.cancer.gov/nci-experimental-therapeutics-program[9]
- CCR Genomics Core
- CAR T-Cell Therapy Development
- Cancer Moonshot Initiatives
Last total enacted budget
The CCR’s budget is not separately detailed but is part of NCI’s $7.2 billion FY 2025 request, with intramural research comprising roughly 20% (~$1.4B) of NCI’s total funding.[10]
Staff
The CCR’s 4,000-strong workforce includes 250+ principal investigators, 1,000+ postdoctoral fellows, clinicians, and support staff, operating at Bethesda’s Building 37 and Frederick’s labs.[11]
Funding
The CCR is funded through NCI’s intramural budget, part of NIH appropriations, supporting its research and clinical operations with no external revenue sources.[12]
Services provided
The CCR conducts basic research in cancer biology, develops translational therapies, runs clinical trials at the NIH Clinical Center (e.g., treating 1,600 patients annually), and provides patient care for rare cancers.[13]
Regulations overseen
The CCR does not oversee regulations but adheres to NIH and federal research policies (e.g., 45 CFR Part 46 for human subjects).[14]
Headquarters address
The headquarters address, as listed on Google Maps, is 37 Convent Drive, Bethesda, MD 20892, USA, within NCI’s Building 37 on the NIH campus.
History
Rooted in NCI’s founding under the 1937 National Cancer Act, the CCR formalized as NCI’s intramural division over decades, gaining prominence with the 1971 Act’s research expansion; key milestones include CAR T-cell therapy advances (2010s) and ongoing Cancer Moonshot contributions.[15]
External links
References
- ↑ "About CCR". Center for Cancer Research. https://ccr.cancer.gov/about.
- ↑ "National Cancer Institute". National Institutes of Health. https://www.nih.gov/about-nih/what-we-do/nih-almanac/national-cancer-institute-nci.
- ↑ "National Cancer Act of 1971". National Cancer Institute. https://www.cancer.gov/about-nci/overview/history/national-cancer-act-1971.
- ↑ "Collaborations". Center for Cancer Research. https://ccr.cancer.gov/about/collaborations.
- ↑ "About CCR". Center for Cancer Research. https://ccr.cancer.gov/about.
- ↑ "Tom Misteli". Center for Cancer Research. https://ccr.cancer.gov/staff-directory/tom-misteli.
- ↑ "Basic Research". Center for Cancer Research. https://ccr.cancer.gov/research/basic-research.
- ↑ "Clinical Research". Center for Cancer Research. https://ccr.cancer.gov/research/clinical-research.
- ↑ "NExT Program". Center for Cancer Research. https://ccr.cancer.gov/nci-experimental-therapeutics-program.
- ↑ "NCI Budget". National Cancer Institute. https://www.cancer.gov/about-nci/budget.
- ↑ "About CCR". Center for Cancer Research. https://ccr.cancer.gov/about.
- ↑ "NCI Budget Fact Book". National Cancer Institute. https://www.cancer.gov/about-nci/budget/fact-book.
- ↑ "Research". Center for Cancer Research. https://ccr.cancer.gov/research.
- ↑ "Research Policies". Center for Cancer Research. https://www.cancer.gov/about-nci/organization/ccr/research-policies.
- ↑ "History". Center for Cancer Research. https://ccr.cancer.gov/about/history.