Acronym O
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- O&M - Operation and Maintenance
- OA - Office of Administration
- OA Office of Audits
- OARM - Office of Attorney Recruitment & Management (DOJ)
- OAS Organization of American States
- OAT French government bond
- OBE - Overcome by Events
- OBL - Office of Business Liason
- OC Office of Communications
- OCC Office of the Comptroller of the Currency, Department of the Treasury
- OCDETF Organized Crime Drug Enforcement Task Force
- OCFO Office of the Chief Financial Officer
- OCIO Office of the Chief Information Office
- OCM Organization Change Management
- OCONUS - Outside the Continental United States
- OCSIT - Office of Citizen Services and Innovative Technologies
- OD Office of the Director
- ODC - Other Direct Costs
- ODEIA Office of Diversity, Equity, Inclusion, and Accessibility
- ODNI - Office of the Director of National Intelligence
- ODNI Office of the Director of National Intelligence
- OE Office of Evaluations
- OECD Organization for Economic Cooperation and Development
- OES/ExecSec Office of the Executive Secretariat
- OESPIM Office of the Executive Secretariat, Privacy, and Information Management
- OFAC Office of Foreign Assets Control, Department of the Treasury
- OFC Offshore Financial Center
- OFM - Office of Financial Management
- OFR - Office of the Federal Register
- OGBS Offshore Group of Banking Supervisors
- OGC Office of the General Counsel
- OGE - Office of Government Ethics
- OGE Office of Government Ethics
- OGP - Office of Government Wide Policy
- OHRP - Office of Human Research Protections
- OI - Office of Intelligence (DOJ)
- OI Office of Investigations
- OIA - Office of International Affairs (DOJ)
- OIG - Office of Inspector General
- OIG - Office of the Inspector General (DOJ)
- OIG Office of the Inspector General
- OIP - Office of Information Policy (DOJ)
- OJP - Office of Justice Programs (DOJ)
- OJP Office of Justice Programs, Department of Justice
- OLA - Office of Legislative Affairs (DOJ)
- OLC - Office of Legal Counsel (DOJ)
- OLE - Office of Legal Education (DOJ)
- OLLA Office of Legal and Legislative Affairs
- OM Office of Management
- OMB - Office of Management & Budget
- OMB - Office of Management and Budget
- OMB Office of Management and Budget
- OMC - Office of Military Commissions
- ONDCP Office of National Drug Control Policy
- ONR - Office of Naval Research
- OPA - Office of Public Affairs (DOJ)
- OPDAT - Office of Overseas Prosecutorial Development, Assistance and Training (DOJ)
- OPIM Office of Privacy and Information Management
- OPM - Office of Personnel Management
- OPM Office of Personnel Management
- OPO Office of Procurement Operations
- OPR - Office of Primary Responsibility
- OPR - Office of Professional Responsibility (DOJ)
- ORCA - Online Representations and Certifications Applications
- OSBP - Office of Small Business Programs
- OSDBU - Office of Small and Disadvantaged Business Utilization
- OSDBU Office of Small and Disadvantaged Business Utilization
- OSHA - Occupational Safety and Health Administration
- OSTI - Office of Scientific and Technical Information
- OTA - Office of Technology Assessment
- OTP - Operational Test Plan
- OTS Office of Thrift Supervision, Department of the Treasury
- OVC - Office for Victims of Crime (DOJ)
- OVT - Office of Justice for Victims of Overseas Terrorism (DOJ)
- OWBO - Office of Women's Business Ownership
- OWCP - Office of Workers' Compensation Programs