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The Genesis Mission is a national initiative launched by the United States government, formalized by an Executive Order signed by President Donald J. Trump on November 25, 2025. This mission aims to revolutionize scientific research and accelerate discovery through the extensive application of artificial intelligence (AI). The Department of Energy (DOE) is central to this effort, tasked with leveraging its National Laboratories, supercomputing capabilities, and vast scientific data to create a cooperative system for research.
Key components of the Genesis Mission include the establishment of a closed-loop AI experimentation platform within the DOE, designed to integrate national supercomputers and unique data assets to generate scientific foundation models and power robotic laboratories. The Assistant to the President for Science and Technology (APST) is responsible for coordinating this national initiative and integrating data and infrastructure across federal agencies. Collaboration with academia and private-sector innovators is also a critical aspect of the mission.
Priority research areas encompass (below) where chosen for their potential to enhance national, economic, and health security.
The Trump Administration anticipates that the Genesis Mission will significantly expand the productivity and impact of federal research and development within a decade by harnessing AI to overcome the perceived stagnation in scientific progress despite increased research budgets.
The website was designed by the National Design Studio.
Announcement
Genesis Mission is building a new instrument for discovery, uniting human curiosity with machine intelligence to double our scientific output and tackle humanity's greatest challenges.
Focus
The Genesis Mission will focus on addressing three key challenges of national importance:
- American energy dominance: The Genesis Mission will accelerate advanced nuclear, fusion, and grid modernization using AI to provide affordable, reliable, and secure energy for Americans.
- Advancing discovery science: Through DOE’s investment and collaboration with industry, America is building the quantum ecosystem that will power discoveries—and industries—for decades to come.
- Ensuring national security: DOE will create advanced AI technologies for national security missions, deploy systems to ensure the safety and reliability of the U.S. nuclear stockpile, and accelerate the development of defense-ready materials.
Functionality
Genesis Mission leverages the Department of Energy's unique scientific datasets-spanning more than 100 petabytes of experimental and simulation data across every major domain of science—to double the pace of American research and innovation within a decade.
Energy
Fusion
Fusion you can plug into
Harnessing the power of the stars to deliver abundant, affordable energy. Through real-time collaboration between scientists, supercomputers, and AI systems, researchers can design, test, and stabilize fusion reactors far faster than ever before, accelerating the realization of sustainable fusion power.
Nuclear
Advanced nuclear, faster and safer
Creating a new generation of more efficient reactor designs, including new modular reactors, that provide reliable, around the clock energy. Engineers and AI tools work together to optimize reactor design, materials, licensing and operations, shortening development timelines while strengthening safety and performance.
Grid
An intelligent, resilient grid
Building a power network that grows as fast as the technologies it fuels. By combining human expertise in energy planning with AI-enabled forecasting and simulation, teams can modernize the nation's grid, improving reliability and accelerating deployment of new infrastructure.
Discovery Science
Molecules
Seeing molecules in action
Revealing chemical and biological processes as they unfold in real time. AI will work with ultrafast experiments to observe molecular dynamics and uncover insights that accelerate breakthroughs in materials and medicine.
Particles
Understanding the universe, from quarks to cosmos
Connecting the smallest particles to the largest structures in existence. Physicists, guided by AI tools that reason across astronomical and particle-physics data, work together to test new theories about dark matter, dark energy, and the laws of nature.
Quantum
Discovering new quantum algorithms
Unlocking the next frontier of computation. AI serves as a reasoning partner for researchers, generating and verifying new classes of quantum algorithms while scientists interpret and validate the results, bringing practical quantum computing closer to reality.
National Security
Materials
Securing critical materials
Reducing dependence on foreign supply chains. Materials scientists and AI systems co-design substitutes, responsibly utilize Earth's resources, and recover rare elements from waste, building a stable, self-reliant foundation for the nation's future industries.
Manufacturing
Accelerating advanced manufacturing
Turning design into production at the speed of need. Engineers and AI-driven digital twins share a continuous feedback loop between design, sensors, and fabrication, cutting qualification time and boosting efficiencies.
Discovery
Discovering mission-ready materials
Delivering alloys, polymers, and composites vital to defense and industry. Human insight and AI-guided discovery converge to fuse simulation, literature mining, and autonomous labs, pointing toward a future where years of materials research could unfold in a fraction of the time.
Essential Information and Guidance
What is Genesis Mission?
A national imitative led by the Department of Energy and its 17 National Laboratories to build the world's most powerful scientific platform to accelerate discover, strength national security, and drive energy innovation.
Why now?
We are in the midst of a revolution in computing, driven by artificial intelligence and quantum information technologies, that will transform how science is done. Genesis Mission has the mission of doubling the productivity and impact of U.S. research and development by pairing scientists with intelligent systems that reason, simulate, and experiment at extraordinary speed.
How does it work?
Genesis Mission will create a national discovery platform that unites the world’s most powerful supercomputers, AI systems, and emerging quantum technologies with the nation’s most advanced scientific instruments. Together, they form and integrated infrastructure for scientific exploration – an intelligent network capable of sensing, simulation, and understanding nature at every scale.
By connecting these systems, Genesis Mission will transform how science is done. It will generate a new class of high-fidelity data to train advanced AI models, empower researchers to solve the hardest scientific challenges, and accelerate discovery from years to months. In doing so, it will serve as both a national accelerator for innovation and a providing ground for the next generation of AI, quantum, and robotics technologies.
What kinds of breakthroughs could it unlock?
From fusion energy and new materials to quantum computing and life-saving medicines, Genesis Mission expands what’s possible in energy, discovery science, and national security.
How is Genesis different from private-sector AI?
Unlike commercial models trained on the open internet, Genesis Mission draws from the government’s secure, multi-domain scientific data, decades of experiments unavailable anywhere else.
Will Genesis Mission use AI to replace scientists?
No. Genesis Mission enables them. It’s AI for discovery, not automation, helping researchers explore and understand the universe faster.
Who's leading it?
The Department of Energy, in partnership with the White House Office of Science and Technology Policy.
Who are the partners in Genesis Mission?
Genesis Mission brings together the Department of Energy’s 17 National Laboratories with America’s leading technology and industrial companies—including pioneers in artificial intelligence, computing, materials, and energy—to build the most powerful scientific platform in history.
These collaborators include organizations such as
- NVIDIA
- AMD
- GE Vernova
- Dell Technologies
Together, they represent the full strength of the U.S. innovation ecosystem, uniting public and private sectors to accelerate discovery and maintain America’s scientific and technological leadership.
How can people get involved?
Genesis Mission is a movement to transform how science is done. DOE will open parts of the Genesis Mission platform to qualified researchers, innovators, and companies, ensuring the benefits of this national effort are shared across the American scientific ecosystem.
Quotes
“Throughout history, from the Manhattan Project to the Apollo mission, our nation’s brightest minds and industries have answered the call when their nation needed them,” said U.S. Secretary of Energy Chris Wright. “Today, the United States is calling on them once again. Under President Trump’s leadership, the Genesis Mission will unleash the full power of our National Laboratories, supercomputers, and data resources to ensure that America is the global leader in artificial intelligence and to usher in a new golden era of American discovery.”
Under Secretary for Science and Genesis Mission Director, Dr. Darío Gil: “The Genesis Mission marks a defining moment for the next era of American science. We are linking the nation’s most advanced facilities, data, and computing into one closed-loop system to create a scientific instrument for the ages, an engine for discovery that doubles R&D productivity and solves challenges once thought impossible.”
Administrator of the National Nuclear Security Administration, Brandon Williams: “The Genesis Mission represents the next great chapter and an unparallelled opportunity for America’s scientific and national security leadership. “Building on decades of innovation and collaboration across our national laboratories, NNSA will leverage AI, quantum computing, and advanced data analytics that will strengthen our deterrents and ensure the United States maintains an unmatched strategic edge over our adversaries. Under President Trump’s leadership, this mission will embody the very best of American ingenuity, turning science and innovation into security.”
Chair of the National Laboratory Directors’ Council, Dr. John Wagner: “DOE’s National Laboratories are engines of discovery that keep the United States competitive and secure. The Genesis Mission unlocks the full potential of these institutions by giving our scientists and engineers tools to work at the speed of innovation. Our laboratories have always risen to meet the nation’s greatest challenges, and this initiative ensures we continue that legacy in the age of artificial intelligence.”