Cancer Systems Biology Consortium

Stored: Cancer Systems Biology Consortium

Cancer Systems Biology Consortium Type: Research and Development Agencies Parent organization: National Cancer Institute Top organization: National Institutes of Health Employees: Executive: Program Director Budget: Address: 9609 Medical Center Drive, Rockville, MD 20850, USA Website: https://csbconsortium.org Creation Legislation: Wikipedia: Cancer Systems Biology Consortium

Cancer Systems Biology Consortium [{"name":"Cancer Systems Biology Consortium","title":"\u003Ca class=\"mw-selflink selflink\"\u003ECancer Systems Biology Consortium\u003C\/a\u003E","lat":39.09808,"lon":-77.18917,"otherValues":{"HeadquartersAddress":"9609 Medical Center Drive, Rockville, MD 20850, USA"}}] This map created from a Cargo query ()

Mission Cancer Systems Biology Consortium advances research by integrating biology and modeling to understand cancer and foster diverse collaboration

Services Research center funding; data sharing platforms; collaborative workshops; outreach programs

Regulations

Cancer Systems Biology Consortium (CSBC) is a multidisciplinary research initiative launched by the National Cancer Institute (NCI) in 2016 to apply systems biology approaches to cancer, administered by NCI’s Division of Cancer Biology from its Shady Grove campus in Rockville, Maryland. Comprising 13 research centers, a coordinating center at Sage Bionetworks, and additional U01 projects, CSBC integrates cancer biologists, engineers, mathematicians, and physicists to address complex cancer challenges like drug resistance, metastasis, and tumor-immune interactions, supported by over $100 million in funding since inception and producing tools like the Cancer Complexity Knowledge Portal.

Official Site

Mission

The Cancer Systems Biology Consortium seeks to deepen understanding of cancer’s fundamental processes by combining experimental data with predictive modeling, tackling its complexity as an integrated system rather than isolated components. It supports innovative research, broadens systems biology applications in cancer, and builds a stable, diverse community through funding, collaboration, and outreach.

Parent organization

The Cancer Systems Biology Consortium operates under the National Cancer Institute, specifically the Division of Cancer Biology, within the National Institutes of Health, part of the Department of Health and Human Services.

Legislation

CSBC was not established by specific legislation but operates under NCI’s authority from the National Cancer Act of 1937, expanded by the National Cancer Act of 1971, with funding initiated via notices like PAR-16-131 in 2016.

Partners

CSBC collaborates with:

• 13 U54 Research Centers (e.g., Columbia, Stanford)
• Sage Bionetworks (Coordinating Center)
• Associate Members from academia and industry

Number of employees

CSBC’s staff size is not specified; it’s managed by NCI DCB personnel, supporting a network of hundreds of investigators across funded centers.

Organization structure

CSBC comprises:

• Research Centers (U54) conduct core projects.
• Coordinating Center (Sage Bionetworks) manages data and outreach.
• U01 Projects support discrete research efforts.

Leader

The Cancer Systems Biology Consortium is overseen by Program Directors within NCI’s Division of Cancer Biology, including Shannon Hughes, Ph.D., and Hannah Dueck, Ph.D.

Divisions

The divisions include:

• U54 Research Centers for interdisciplinary systems biology.
• U01 Projects for targeted studies.
• Coordinating Center for data integration and community support.

List of programs

CSBC oversees:

• U54 Research Centers - https://csbconsortium.org/research-portfolio
• U01 Research Projects
• Cancer Complexity Knowledge Portal

Last total enacted budget

CSBC’s budget isn’t separately itemized; it’s part of NCI’s $7.2B FY 2025 request, with initial funding (~$100M since 2016) inferred from grant scales (e.g., U54s ~$2M/year).

Staff

CSBC lacks a distinct staff count; NCI DCB oversees it, supporting ~400 investigators across 13 centers plus U01s, per consortium scope.

Funding

CSBC is funded through NCI’s extramural budget via NIH appropriations, supporting U54 centers, U01 projects, and the Coordinating Center.

Services provided

CSBC funds research centers, provides data platforms (e.g., Cancer Complexity Knowledge Portal), hosts workshops, and supports outreach to advance systems biology.

Regulations overseen

CSBC does not oversee regulations but adheres to NIH grant policies (e.g., 45 CFR Part 75).

Headquarters address

The headquarters address, as listed on Google Maps, is 9609 Medical Center Drive, Rockville, MD 20850, USA, within NCI’s Shady Grove campus.

History

Launched in 2016 via PAR-16-131, CSBC built on NCI’s systems biology efforts since 2004, awarding initial U54 centers and expanding with four new centers in 2022 to tackle drug resistance and metastasis.

External links

• Official Website
• wikipedia:Cancer_Systems_Biology_Consortium
• NCI DCB Overview