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The '''Diabetes Prevention Program Outcomes Study''' (DPPOS) is a long-term follow-up research program led by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) within the Department of Health and Human Services, building on the foundational Diabetes Prevention Program (DPP) that concluded in 2002. Launched in 2002, DPPOS tracks the original DPP cohort—over 3,000 participants—to examine the sustained impact of intensive lifestyle interventions (achieving 7% weight loss and 150 minutes of weekly exercise) and metformin on type 2 diabetes prevention, as well as their effects on cardiovascular disease, cancer, and aging-related outcomes, providing critical data for public health strategies. {{Official URL (simple)|url=https://dppos.bsc.gwu.edu/}} ==Goals== * Assess the long-term efficacy of DPP lifestyle and metformin interventions in preventing or delaying type 2 diabetes over 20+ years. * Investigate the impact of these interventions on diabetes-related complications, cardiovascular risk, and overall mortality. * Provide longitudinal data to inform clinical guidelines, targeting sustained risk reduction in the original high-risk cohort. ==Organization== The Diabetes Prevention Program Outcomes Study is managed by the NIDDK, with operational coordination through the George Washington University Biostatistics Center, which serves as the central data hub. It retains the DPP’s network of 27 clinical sites, where participants receive periodic health assessments and optional booster interventions. Funding is sourced from NIH appropriations, supplemented by contributions from the National Institute on Aging and other institutes, though initial DPPOS-specific amounts are not publicly detailed beyond the original DPP’s $174.3 million. Governance involves a steering committee of investigators and NIDDK representatives, ensuring scientific rigor. The program’s leader holds the title of **DPPOS Study Chair**, currently David M. Nathan, M.D., who transitioned from the DPP to lead this phase. ==History== The DPPOS was established in 2002 as a direct continuation of the [[Diabetes Prevention Program]], authorized under [[Public Law 103-183]], the "National Institutes of Health Revitalization Act of 1993," which empowered NIH to pursue long-term health research. It emerged from the DPP’s 2001 findings—showing lifestyle changes reduced diabetes risk by 58%—to address questions about durability and broader health impacts. Key milestones include its 10-year results in 2012, confirming sustained benefits, and its 20-year follow-up data by 2022. The program has evolved to include aging-related outcomes, with plans to continue through at least 2026, supported by ongoing NIH funding and participant retention efforts. ==Funding== The DPPOS is financed through NIH budgets, building on the DPP’s $174.3 million investment, though specific initial funding for DPPOS in 2002 is not publicly isolated. Funding began in 2002 and remains ongoing, with periodic NIH grants—such as a $15 million renewal in 2016—supporting follow-up phases. It has no defined end date, with additional funding authorized as needed to extend data collection, relying on federal research allocations and multi-institute collaboration for sustained operations. ==Implementation== The DPPOS is carried out through observational follow-up of the DPP cohort, with annual or biannual health assessments tracking diabetes incidence, complications, and other outcomes. Methods include maintaining contact with participants via clinic visits, phone calls, and questionnaires, with some offered booster lifestyle sessions to reinforce prior interventions. Implementation began in 2002 after DPP’s conclusion, with no fixed end date, aiming for indefinite data collection as long as funding and participant participation persist. Strategies focus on long-term retention and adapting assessments to aging participants. ==Related== * [[Diabetes Prevention Program]] * [[National Institute of Diabetes and Digestive and Kidney Diseases]] * [[National Diabetes Prevention Program]] ==External links== * https://dppos.bsc.gwu.edu/ * https://www.niddk.nih.gov/about-niddk/research-areas/diabetes/diabetes-prevention-program-dpp * [[wikipedia:Diabetes Prevention Program]] ===Social media=== * https://twitter.com/NIDDKgov ==References== <references /> [[Category:Programs and initiatives]] [[Category:Programs]] [[Category:Department of Health and Human Services]]